WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP

The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely unexplored. In this study, we explored the role of WIPI2 in PINK1-PRKN/parkin-me...

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Detalles Bibliográficos
Autores principales: Lu, Guang, Tan, Hayden Weng Siong, Schmauck-Medina, Tomas, Wang, Liming, Chen, Jiaqing, Cho, Yik-Lam, Chen, Kelie, Zhang, Jing-Zi, He, Weifeng, Wu, Yihua, Xia, Dajing, Zhou, Jing, Fang, Evandro F., Fang, Lei, Liu, Wei, Shen, Han-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673930/
https://www.ncbi.nlm.nih.gov/pubmed/35389758
http://dx.doi.org/10.1080/15548627.2022.2052461

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