Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes

Astrocytes, often considered as secondary responders to neurodegeneration, are emerging as primary drivers of brain disease. Here we show that mitochondrial DNA depletion in astrocytes affects their primary cilium, the signaling organelle of a cell. The progressive oxidative phosphorylation deficien...

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Detalles Bibliográficos
Autores principales: Ignatenko, Olesia, Malinen, Satu, Rybas, Sofiia, Vihinen, Helena, Nikkanen, Joni, Kononov, Aleksander, Jokitalo, Eija S., Ince-Dunn, Gulayse, Suomalainen, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674092/
https://www.ncbi.nlm.nih.gov/pubmed/36383135
http://dx.doi.org/10.1083/jcb.202203019

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