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A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity

Anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis is a rare autoimmune disorder, classified within limbic encephalitides, and characterized by seizures and subacute cognitive-behavioral impairment, mainly affecting short-term memory and usually involving temporo-mesial lobe str...

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Detalles Bibliográficos
Autores principales: Papiri, Giulio, Puca, Emanuele, Marcucci, Matteo, Paci, Cristina, Cagnetti, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674110/
https://www.ncbi.nlm.nih.gov/pubmed/36415395
http://dx.doi.org/10.7759/cureus.30480
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author Papiri, Giulio
Puca, Emanuele
Marcucci, Matteo
Paci, Cristina
Cagnetti, Claudia
author_facet Papiri, Giulio
Puca, Emanuele
Marcucci, Matteo
Paci, Cristina
Cagnetti, Claudia
author_sort Papiri, Giulio
collection PubMed
description Anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis is a rare autoimmune disorder, classified within limbic encephalitides, and characterized by seizures and subacute cognitive-behavioral impairment, mainly affecting short-term memory and usually involving temporo-mesial lobe structures. We present a case of anti-LGI1 encephalitis characterized by focal right lower limb motor seizures and pyramidal signs and responsive to high-dose methylprednisolone. The patient developed an atypical left frontal lobe parasagittal T2 hyperintense lesion on MRI within one month of hospital admission, which has not been described previously in this disease to the best of our knowledge.
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spelling pubmed-96741102022-11-21 A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity Papiri, Giulio Puca, Emanuele Marcucci, Matteo Paci, Cristina Cagnetti, Claudia Cureus Neurology Anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis is a rare autoimmune disorder, classified within limbic encephalitides, and characterized by seizures and subacute cognitive-behavioral impairment, mainly affecting short-term memory and usually involving temporo-mesial lobe structures. We present a case of anti-LGI1 encephalitis characterized by focal right lower limb motor seizures and pyramidal signs and responsive to high-dose methylprednisolone. The patient developed an atypical left frontal lobe parasagittal T2 hyperintense lesion on MRI within one month of hospital admission, which has not been described previously in this disease to the best of our knowledge. Cureus 2022-10-19 /pmc/articles/PMC9674110/ /pubmed/36415395 http://dx.doi.org/10.7759/cureus.30480 Text en Copyright © 2022, Papiri et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Papiri, Giulio
Puca, Emanuele
Marcucci, Matteo
Paci, Cristina
Cagnetti, Claudia
A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity
title A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity
title_full A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity
title_fullStr A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity
title_full_unstemmed A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity
title_short A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Encephalitis With an Unusual Frontomesial Motor Cortex T2 MRI Hyperintensity
title_sort case of anti-leucine-rich glioma-inactivated protein 1 (anti-lgi1) encephalitis with an unusual frontomesial motor cortex t2 mri hyperintensity
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674110/
https://www.ncbi.nlm.nih.gov/pubmed/36415395
http://dx.doi.org/10.7759/cureus.30480
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