Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains

SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospectively characterizes the impacts of mutations on these biochemical properties, enabling rapid assessmen...

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Detalles Bibliográficos
Autores principales: Starr, Tyler N., Greaney, Allison J., Stewart, Cameron M., Walls, Alexandra C., Hannon, William W., Veesler, David, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674177/
https://www.ncbi.nlm.nih.gov/pubmed/36399443
http://dx.doi.org/10.1371/journal.ppat.1010951

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