Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

Inactivation of Capicua (CIC) or upregulation of yes-associated protein 1, YAP1, leads to broad RAS-RAF-MEK-ERK inhibitor resistance and tumor progression in multiple human cancers. Despite these shared malignant phenotypes, it remains unclear whether CIC and YAP1 are mechanistically linked. Here, w...

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Detalles Bibliográficos
Autores principales: Kim, Ji Won, Luck, Cuyler, Wu, Wei, Ponce, Rovingaile Kriska, Lin, Yone Kawe, Gupta, Nehal, Okimoto, Ross A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674208/
https://www.ncbi.nlm.nih.gov/pubmed/36198276
http://dx.doi.org/10.1016/j.celrep.2022.111443

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