Genetically-encoded BRET probes shed light on ligand bias–induced variable ion selectivity in TRPV1 and P2X5/7

Whether ion channels experience ligand-dependent dynamic ion selectivity remains of critical importance since this could support ion channel functional bias. Tracking selective ion permeability through ion channels, however, remains challenging even with patch-clamp electrophysiology. In this study,...

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Detalles Bibliográficos
Autores principales: Chappe, Yann Loïck, Pierredon, Sandra, Joushomme, Alexandre, Molle, Pablo, Garenne, André, Canovi, Anne, Barbeau, Solène, Poulletier De Gannes, Florence, Hurtier, Annabelle, Lagroye, Isabelle, Ducret, Thomas, Quignard, Jean-François, Compan, Vincent, Percherancier, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674215/
https://www.ncbi.nlm.nih.gov/pubmed/36343259
http://dx.doi.org/10.1073/pnas.2205207119

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