SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms

The in vivo mechanisms underlying dominant syndromes caused by mutations in SRY-Box Transcription Factor 9 (SOX9) and SOX10 (SOXE) transcription factors, when they either are expressed alone or are coexpressed, are ill-defined. We created a mouse model for the campomelic dysplasia SOX9(Y440X) mutati...

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Detalles Bibliográficos
Autores principales: Szeto, Irene Y. Y., Chu, Daniel K. H., Chen, Peikai, Chu, Ka Chi, Au, Tiffany Y. K., Leung, Keith K. H., Huang, Yong-Heng, Wynn, Sarah L., Mak, Angel C. Y., Chan, Ying-Shing, Chan, Wood Yee, Jauch, Ralf, Fritzsch, Bernd, Sham, Mai Har, Lovell-Badge, Robin, Cheah, Kathryn S. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674217/
https://www.ncbi.nlm.nih.gov/pubmed/36343245
http://dx.doi.org/10.1073/pnas.2122121119

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