Hedgehog-interacting protein acts in the habenula to regulate nicotine intake

Hedgehog-interacting protein (HHIP) sequesters Hedgehog ligands to repress Smoothened (SMO)-mediated recruitment of the GLI family of transcription factors. Allelic variation in HHIP confers risk of chronic obstructive pulmonary disease and other smoking-related lung diseases, but underlying mechani...

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Detalles Bibliográficos
Autores principales: Caligiuri, Stephanie P. B., Howe, William M., Wills, Lauren, Smith, Alexander C. W., Lei, Ye, Bali, Purva, Heyer, Mary P., Moen, Janna K., Ables, Jessica L., Elayouby, Karim S., Williams, Maya, Fillinger, Clementine, Oketokoun, Zainab, Lehmann, Vanessa E., DiFeliceantonio, Alexandra G., Johnson, Paul M., Beaumont, Kristin, Sebra, Robert P., Ibanez-Tallon, Ines, Kenny, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674224/
https://www.ncbi.nlm.nih.gov/pubmed/36346845
http://dx.doi.org/10.1073/pnas.2209870119

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