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Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models

Enteroendocrine cells (EECs) secrete hormones in response to ingested nutrients to control physiological processes such as appetite and insulin release. EEC hormones are synthesized as large proproteins that undergo proteolytic processing to generate bioactive peptides. Mutations in EEC-enriched pro...

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Detalles Bibliográficos
Autores principales:	Beumer, Joep, Bauzá-Martinez, Julia, Veth, Tim S., Geurts, Veerle, Boot, Charelle, Gilliam-Vigh, Hannah, Poulsen, Steen S., Knop, Filip K., Wu, Wei, Clevers, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674236/ https://www.ncbi.nlm.nih.gov/pubmed/36343264 http://dx.doi.org/10.1073/pnas.2212057119

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