Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family

Neuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional regulator whose dysfunction has been linked to a variety of neuropsychiatric and metabolic diseases. As a member of the basic helix–loop–helix PER-ARNT-SIM (bHLH-PAS) transcription factor family, NPAS4 is distinguis...

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Detalles Bibliográficos
Autores principales: Sun, Xiangnan, Jing, Linqian, Li, Fengwei, Zhang, Meina, Diao, Xiaotong, Zhuang, Jingjing, Rastinejad, Fraydoon, Wu, Dalei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674253/
https://www.ncbi.nlm.nih.gov/pubmed/36343253
http://dx.doi.org/10.1073/pnas.2208804119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674253/
https://www.ncbi.nlm.nih.gov/pubmed/36343253
http://dx.doi.org/10.1073/pnas.2208804119

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