Nonstop mRNAs generate a ground state of mitochondrial gene expression noise

A stop codon within the mRNA facilitates coordinated termination of protein synthesis, releasing the nascent polypeptide from the ribosome. This essential step in gene expression is impeded with transcripts lacking a stop codon, generating nonstop ribosome complexes. Here, we use deep sequencing to...

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Detalles Bibliográficos
Autores principales: Ng, Kah Ying, Lutfullahoglu Bal, Guleycan, Richter, Uwe, Safronov, Omid, Paulin, Lars, Dunn, Cory D., Paavilainen, Ville O., Richer, Julie, Newman, William G., Taylor, Robert W., Battersby, Brendan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674279/
https://www.ncbi.nlm.nih.gov/pubmed/36399564
http://dx.doi.org/10.1126/sciadv.abq5234

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