Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity

Alzheimer’s disease (AD) is a heterogeneous disorder with abnormalities in multiple biological domains. In an advanced machine learning analysis of postmortem brain and in vivo blood multi-omics molecular data (N = 1863), we integrated epigenomic, transcriptomic, proteomic, and metabolomic profiles...

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Detalles Bibliográficos
Autores principales: Iturria-Medina, Yasser, Adewale, Quadri, Khan, Ahmed F., Ducharme, Simon, Rosa-Neto, Pedro, O’Donnell, Kieran, Petyuk, Vladislav A., Gauthier, Serge, De Jager, Philip L., Breitner, John, Bennett, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674284/
https://www.ncbi.nlm.nih.gov/pubmed/36399579
http://dx.doi.org/10.1126/sciadv.abo6764

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