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Pore forming–mediated intracellular protein delivery for enhanced cancer immunotherapy

Directly delivering therapeutic proteins to their intracellular targets remains a great challenge. Here, we apply CD8(+) T cells to form pores on the tumor cells’ plasma membranes, enabling perfusion of ribonuclease A (RNase A) and granzyme B into cells, therefore effectively inducing tumor apoptosi...

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Detalles Bibliográficos
Autores principales:	Zhou, Zhanwei, Yang, Ruoxi, Dong, Jingwen, Di, Yongxiang, Yang, Ying, Huang, Ying, Yang, Xue, Liu, Wei, Wang, Jinqiang, Liu, Peifeng, Gu, Zhen, Sun, Minjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674288/ https://www.ncbi.nlm.nih.gov/pubmed/36399575 http://dx.doi.org/10.1126/sciadv.abq4659

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