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Genetic slippage after sex maintains diversity for parasite resistance in a natural host population
Although parasite-mediated selection is a major driver of host evolution, its influence on genetic variation for parasite resistance is not yet well understood. We monitored resistance in a large population of the planktonic crustacean Daphnia magna over 8 years, as it underwent yearly epidemics of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674289/ https://www.ncbi.nlm.nih.gov/pubmed/36399570 http://dx.doi.org/10.1126/sciadv.abn0051 |
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author | Ameline, Camille Voegtli, Felix Andras, Jason Dexter, Eric Engelstädter, Jan Ebert, Dieter |
author_facet | Ameline, Camille Voegtli, Felix Andras, Jason Dexter, Eric Engelstädter, Jan Ebert, Dieter |
author_sort | Ameline, Camille |
collection | PubMed |
description | Although parasite-mediated selection is a major driver of host evolution, its influence on genetic variation for parasite resistance is not yet well understood. We monitored resistance in a large population of the planktonic crustacean Daphnia magna over 8 years, as it underwent yearly epidemics of the bacterial pathogen Pasteuria ramosa. We observed cyclic dynamics of resistance: Resistance increased throughout the epidemics, but susceptibility was restored each spring when hosts hatched from sexual resting stages. Host resting stages collected across the year showed that largely resistant host populations can produce susceptible sexual offspring. A genetic model of resistance developed for this host-parasite system, based on multiple loci and strong epistasis, is in partial agreement with our findings. Our results reveal that, despite strong selection for resistance in a natural host population, genetic slippage after sexual reproduction can be a strong factor for the maintenance of genetic diversity of host resistance. |
format | Online Article Text |
id | pubmed-9674289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96742892022-11-29 Genetic slippage after sex maintains diversity for parasite resistance in a natural host population Ameline, Camille Voegtli, Felix Andras, Jason Dexter, Eric Engelstädter, Jan Ebert, Dieter Sci Adv Biomedicine and Life Sciences Although parasite-mediated selection is a major driver of host evolution, its influence on genetic variation for parasite resistance is not yet well understood. We monitored resistance in a large population of the planktonic crustacean Daphnia magna over 8 years, as it underwent yearly epidemics of the bacterial pathogen Pasteuria ramosa. We observed cyclic dynamics of resistance: Resistance increased throughout the epidemics, but susceptibility was restored each spring when hosts hatched from sexual resting stages. Host resting stages collected across the year showed that largely resistant host populations can produce susceptible sexual offspring. A genetic model of resistance developed for this host-parasite system, based on multiple loci and strong epistasis, is in partial agreement with our findings. Our results reveal that, despite strong selection for resistance in a natural host population, genetic slippage after sexual reproduction can be a strong factor for the maintenance of genetic diversity of host resistance. American Association for the Advancement of Science 2022-11-18 /pmc/articles/PMC9674289/ /pubmed/36399570 http://dx.doi.org/10.1126/sciadv.abn0051 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Ameline, Camille Voegtli, Felix Andras, Jason Dexter, Eric Engelstädter, Jan Ebert, Dieter Genetic slippage after sex maintains diversity for parasite resistance in a natural host population |
title | Genetic slippage after sex maintains diversity for parasite resistance in a natural host population |
title_full | Genetic slippage after sex maintains diversity for parasite resistance in a natural host population |
title_fullStr | Genetic slippage after sex maintains diversity for parasite resistance in a natural host population |
title_full_unstemmed | Genetic slippage after sex maintains diversity for parasite resistance in a natural host population |
title_short | Genetic slippage after sex maintains diversity for parasite resistance in a natural host population |
title_sort | genetic slippage after sex maintains diversity for parasite resistance in a natural host population |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674289/ https://www.ncbi.nlm.nih.gov/pubmed/36399570 http://dx.doi.org/10.1126/sciadv.abn0051 |
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