CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy

Tumors exploit numerous immune checkpoints, including those deployed by myeloid cells to curtail antitumor immunity. Here, we show that the C-type lectin receptor CLEC-1 expressed by myeloid cells senses dead cells killed by programmed necrosis. Moreover, we identified Tripartite Motif Containing 21...

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Detalles Bibliográficos
Autores principales: Drouin, Marion, Saenz, Javier, Gauttier, Vanessa, Evrard, Berangere, Teppaz, Geraldine, Pengam, Sabrina, Mary, Caroline, Desselle, Ariane, Thepenier, Virginie, Wilhelm, Emmanuelle, Merieau, Emmanuel, Ligeron, Camille, Girault, Isabelle, Lopez, Maria-Dolores, Fourgeux, Cynthia, Sinha, Debajyoti, Baccelli, Irene, Moreau, Aurelie, Louvet, Cedric, Josien, Regis, Poschmann, Jeremie, Poirier, Nicolas, Chiffoleau, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674301/
https://www.ncbi.nlm.nih.gov/pubmed/36399563
http://dx.doi.org/10.1126/sciadv.abo7621

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