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Development of visual cortex in human neonates is selectively modified by postnatal experience

Experience-dependent cortical plasticity is a pivotal process of human brain development and essential for the formation of most cognitive functions. Although studies found that early visual experience could influence the endogenous development of visual cortex in animals, little is known about such...

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Autores principales: Li, Mingyang, Liu, Tingting, Xu, Xinyi, Wen, Qingqing, Zhao, Zhiyong, Dang, Xixi, Zhang, Yi, Wu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674344/
https://www.ncbi.nlm.nih.gov/pubmed/36399034
http://dx.doi.org/10.7554/eLife.78733
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author Li, Mingyang
Liu, Tingting
Xu, Xinyi
Wen, Qingqing
Zhao, Zhiyong
Dang, Xixi
Zhang, Yi
Wu, Dan
author_facet Li, Mingyang
Liu, Tingting
Xu, Xinyi
Wen, Qingqing
Zhao, Zhiyong
Dang, Xixi
Zhang, Yi
Wu, Dan
author_sort Li, Mingyang
collection PubMed
description Experience-dependent cortical plasticity is a pivotal process of human brain development and essential for the formation of most cognitive functions. Although studies found that early visual experience could influence the endogenous development of visual cortex in animals, little is known about such impact on human infants. Using the multimodal MRI data from the developing human connectome project, we characterized the early structural and functional maps in the ventral visual cortex and their development during neonatal period. Particularly, we found that postnatal time selectively modulated the cortical thickness in the ventral visual cortex and the functional circuit between bilateral primary visual cortices. But the cortical myelination and functional connections of the high-order visual cortex developed without significant influence of postnatal time in such an early period. The structure–function analysis further revealed that the postnatal time had a direct influence on the development of homotopic connection in area V1, while gestational time had an indirect effect on it through cortical myelination. These findings were further validated in preterm-born infants who had longer postnatal time but shorter gestational time at birth. In short, these data suggested in human newborns that early postnatal time shaped the structural and functional development of the visual cortex in selective and organized patterns.
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spelling pubmed-96743442022-11-19 Development of visual cortex in human neonates is selectively modified by postnatal experience Li, Mingyang Liu, Tingting Xu, Xinyi Wen, Qingqing Zhao, Zhiyong Dang, Xixi Zhang, Yi Wu, Dan eLife Neuroscience Experience-dependent cortical plasticity is a pivotal process of human brain development and essential for the formation of most cognitive functions. Although studies found that early visual experience could influence the endogenous development of visual cortex in animals, little is known about such impact on human infants. Using the multimodal MRI data from the developing human connectome project, we characterized the early structural and functional maps in the ventral visual cortex and their development during neonatal period. Particularly, we found that postnatal time selectively modulated the cortical thickness in the ventral visual cortex and the functional circuit between bilateral primary visual cortices. But the cortical myelination and functional connections of the high-order visual cortex developed without significant influence of postnatal time in such an early period. The structure–function analysis further revealed that the postnatal time had a direct influence on the development of homotopic connection in area V1, while gestational time had an indirect effect on it through cortical myelination. These findings were further validated in preterm-born infants who had longer postnatal time but shorter gestational time at birth. In short, these data suggested in human newborns that early postnatal time shaped the structural and functional development of the visual cortex in selective and organized patterns. eLife Sciences Publications, Ltd 2022-11-18 /pmc/articles/PMC9674344/ /pubmed/36399034 http://dx.doi.org/10.7554/eLife.78733 Text en © 2022, Li et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Li, Mingyang
Liu, Tingting
Xu, Xinyi
Wen, Qingqing
Zhao, Zhiyong
Dang, Xixi
Zhang, Yi
Wu, Dan
Development of visual cortex in human neonates is selectively modified by postnatal experience
title Development of visual cortex in human neonates is selectively modified by postnatal experience
title_full Development of visual cortex in human neonates is selectively modified by postnatal experience
title_fullStr Development of visual cortex in human neonates is selectively modified by postnatal experience
title_full_unstemmed Development of visual cortex in human neonates is selectively modified by postnatal experience
title_short Development of visual cortex in human neonates is selectively modified by postnatal experience
title_sort development of visual cortex in human neonates is selectively modified by postnatal experience
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674344/
https://www.ncbi.nlm.nih.gov/pubmed/36399034
http://dx.doi.org/10.7554/eLife.78733
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