Cargando…

Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19

BACKGROUND: Sarcopenia is associated with negative outcomes in intensive care unit (ICU) patients and during chronic diseases. We aimed to evaluate if low skeletal muscle index (SMI) measured by computed tomography (CT) at the thoracic level is associated with poor outcomes in hospitalized patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Grigioni, S., Lvovschi, V.-E., Tamion, F., Joly, L.-M., Coëffier, M., Van Elslande, H., Galmiche, Marie, Gâté, M., Traore-Ouattara, U., Marais, B., Michel, J., Dechelotte, P., Savoye-Collet, C., Achamrah, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674398/
https://www.ncbi.nlm.nih.gov/pubmed/36521254
http://dx.doi.org/10.1016/j.clnu.2022.11.011
_version_ 1784833143682891776
author Grigioni, S.
Lvovschi, V.-E.
Tamion, F.
Joly, L.-M.
Coëffier, M.
Van Elslande, H.
Galmiche, Marie
Gâté, M.
Traore-Ouattara, U.
Marais, B.
Michel, J.
Dechelotte, P.
Savoye-Collet, C.
Achamrah, N.
author_facet Grigioni, S.
Lvovschi, V.-E.
Tamion, F.
Joly, L.-M.
Coëffier, M.
Van Elslande, H.
Galmiche, Marie
Gâté, M.
Traore-Ouattara, U.
Marais, B.
Michel, J.
Dechelotte, P.
Savoye-Collet, C.
Achamrah, N.
author_sort Grigioni, S.
collection PubMed
description BACKGROUND: Sarcopenia is associated with negative outcomes in intensive care unit (ICU) patients and during chronic diseases. We aimed to evaluate if low skeletal muscle index (SMI) measured by computed tomography (CT) at the thoracic level is associated with poor outcomes in hospitalized patients with respiratory COVID-19. METHODS: Patients admitted to the hospital between March 1st and June 9, 2020 with a confirmed diagnosis of respiratory COVID-19 in the Emergency Department were included in this retrospective cohort study. SMI was assessed from a transverse CT image at the T12 level. We analysed the association between thoracic SMI and mortality, ICU admissions, infections, length of stay and gravity scores. RESULTS: We included 244 patients, whose median age was 62 (20–95) years, mean body mass index was 28,6 kg/m(2), and 34% were obese patients. 102 patients (41,8%) had low thoracic SMI. On multivariable analysis, low thoracic SMI was associated with more infections (OR = 1,88 [1,06-2,98]) and increased length of stay (OR = 1,87 [1,14-3,49]) but not with mortality (OR = 1.37 [0.54–3.52]), whereas it was inversely associated with ICU admission (OR = 5,56 [1,96-16,67]. CONCLUSION: Low SMI measured by CT at the thoracic level T12 is associated with negative outcomes in patients with respiratory COVID-19.
format Online
Article
Text
id pubmed-9674398
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Author(s). Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-96743982022-11-21 Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19 Grigioni, S. Lvovschi, V.-E. Tamion, F. Joly, L.-M. Coëffier, M. Van Elslande, H. Galmiche, Marie Gâté, M. Traore-Ouattara, U. Marais, B. Michel, J. Dechelotte, P. Savoye-Collet, C. Achamrah, N. Clin Nutr Covid-19 BACKGROUND: Sarcopenia is associated with negative outcomes in intensive care unit (ICU) patients and during chronic diseases. We aimed to evaluate if low skeletal muscle index (SMI) measured by computed tomography (CT) at the thoracic level is associated with poor outcomes in hospitalized patients with respiratory COVID-19. METHODS: Patients admitted to the hospital between March 1st and June 9, 2020 with a confirmed diagnosis of respiratory COVID-19 in the Emergency Department were included in this retrospective cohort study. SMI was assessed from a transverse CT image at the T12 level. We analysed the association between thoracic SMI and mortality, ICU admissions, infections, length of stay and gravity scores. RESULTS: We included 244 patients, whose median age was 62 (20–95) years, mean body mass index was 28,6 kg/m(2), and 34% were obese patients. 102 patients (41,8%) had low thoracic SMI. On multivariable analysis, low thoracic SMI was associated with more infections (OR = 1,88 [1,06-2,98]) and increased length of stay (OR = 1,87 [1,14-3,49]) but not with mortality (OR = 1.37 [0.54–3.52]), whereas it was inversely associated with ICU admission (OR = 5,56 [1,96-16,67]. CONCLUSION: Low SMI measured by CT at the thoracic level T12 is associated with negative outcomes in patients with respiratory COVID-19. The Author(s). Published by Elsevier Ltd. 2023-02 2022-11-19 /pmc/articles/PMC9674398/ /pubmed/36521254 http://dx.doi.org/10.1016/j.clnu.2022.11.011 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Covid-19
Grigioni, S.
Lvovschi, V.-E.
Tamion, F.
Joly, L.-M.
Coëffier, M.
Van Elslande, H.
Galmiche, Marie
Gâté, M.
Traore-Ouattara, U.
Marais, B.
Michel, J.
Dechelotte, P.
Savoye-Collet, C.
Achamrah, N.
Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19
title Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19
title_full Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19
title_fullStr Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19
title_full_unstemmed Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19
title_short Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19
title_sort low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory covid-19
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674398/
https://www.ncbi.nlm.nih.gov/pubmed/36521254
http://dx.doi.org/10.1016/j.clnu.2022.11.011
work_keys_str_mv AT grigionis lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT lvovschive lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT tamionf lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT jolylm lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT coeffierm lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT vanelslandeh lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT galmichemarie lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT gatem lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT traoreouattarau lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT maraisb lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT michelj lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT dechelottep lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT savoyecolletc lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19
AT achamrahn lowthoracicskeletalmuscleindexisassociatedwithnegativeoutcomesin244patientswithrespiratorycovid19