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Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis

Increasing evidence suggests that early-life bacillus Calmette-Guérin (BCG) vaccine could prevent atopic eczema through its beneficial off-target effects. In this meta-analysis, 3 randomized control trials with similar methods were included and enabled robust estimations with low heterogeneity, invo...

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Autores principales: Pittet, Laure F., Thøstesen, Lisbeth M., Aaby, Peter, Kofoed, Poul-Erik, Curtis, Nigel, Benn, Christine S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674447/
https://www.ncbi.nlm.nih.gov/pubmed/36125788
http://dx.doi.org/10.1097/DER.0000000000000945
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author Pittet, Laure F.
Thøstesen, Lisbeth M.
Aaby, Peter
Kofoed, Poul-Erik
Curtis, Nigel
Benn, Christine S.
author_facet Pittet, Laure F.
Thøstesen, Lisbeth M.
Aaby, Peter
Kofoed, Poul-Erik
Curtis, Nigel
Benn, Christine S.
author_sort Pittet, Laure F.
collection PubMed
description Increasing evidence suggests that early-life bacillus Calmette-Guérin (BCG) vaccine could prevent atopic eczema through its beneficial off-target effects. In this meta-analysis, 3 randomized control trials with similar methods were included and enabled robust estimations with low heterogeneity, involving a total of 5655 children randomized to early-life BCG Denmark (n = 2832) or no BCG (n = 2823). Meta-analyses suggest a beneficial effect of BCG to prevent eczema (risk ratio [RR], 0.89; 95% confidence interval [CI], 0.82–0.98). In subgroup analyses, BCG was more beneficial in boys (RR, 0.84; 95% CI, 0.74–0.95) and in children born to 2 atopic parents (RR, 0.81; 95% CI, 0.68–0.97). The NNT to prevent one case of eczema among children of 1 or 2 atopic parent was 20 (95% CI, 12–50). Bacillus Calmette-Guérin Denmark leads to an 11% reduction in the risk of eczema in early life. A greater effect was observed with increasing predisposition. Given its well-established safety profile, neonatal BCG vaccination should be considered for children of atopic parents.
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spelling pubmed-96744472022-11-28 Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis Pittet, Laure F. Thøstesen, Lisbeth M. Aaby, Peter Kofoed, Poul-Erik Curtis, Nigel Benn, Christine S. Dermatitis Reviews Increasing evidence suggests that early-life bacillus Calmette-Guérin (BCG) vaccine could prevent atopic eczema through its beneficial off-target effects. In this meta-analysis, 3 randomized control trials with similar methods were included and enabled robust estimations with low heterogeneity, involving a total of 5655 children randomized to early-life BCG Denmark (n = 2832) or no BCG (n = 2823). Meta-analyses suggest a beneficial effect of BCG to prevent eczema (risk ratio [RR], 0.89; 95% confidence interval [CI], 0.82–0.98). In subgroup analyses, BCG was more beneficial in boys (RR, 0.84; 95% CI, 0.74–0.95) and in children born to 2 atopic parents (RR, 0.81; 95% CI, 0.68–0.97). The NNT to prevent one case of eczema among children of 1 or 2 atopic parent was 20 (95% CI, 12–50). Bacillus Calmette-Guérin Denmark leads to an 11% reduction in the risk of eczema in early life. A greater effect was observed with increasing predisposition. Given its well-established safety profile, neonatal BCG vaccination should be considered for children of atopic parents. Lippincott Williams & Wilkins 2022 2022-09-22 /pmc/articles/PMC9674447/ /pubmed/36125788 http://dx.doi.org/10.1097/DER.0000000000000945 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Contact Dermatitis Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Reviews
Pittet, Laure F.
Thøstesen, Lisbeth M.
Aaby, Peter
Kofoed, Poul-Erik
Curtis, Nigel
Benn, Christine S.
Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis
title Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis
title_full Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis
title_fullStr Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis
title_full_unstemmed Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis
title_short Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis
title_sort neonatal bacillus calmette-guérin vaccination to prevent early-life eczema: a systematic review and meta-analysis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674447/
https://www.ncbi.nlm.nih.gov/pubmed/36125788
http://dx.doi.org/10.1097/DER.0000000000000945
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