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The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by suppurative infection, sinus tract, and abscess formation. International management guidelines are largely consensus-based. Botulinum toxin (BTX) has been widely used in the treatment of apocrine and eccrine glan...

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Autores principales: Geoghegan, Luke, Rodrigues, Raina, Harrison, Conrad J., Rodrigues, Jeremy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674480/
https://www.ncbi.nlm.nih.gov/pubmed/36415615
http://dx.doi.org/10.1097/GOX.0000000000004660
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author Geoghegan, Luke
Rodrigues, Raina
Harrison, Conrad J.
Rodrigues, Jeremy N.
author_facet Geoghegan, Luke
Rodrigues, Raina
Harrison, Conrad J.
Rodrigues, Jeremy N.
author_sort Geoghegan, Luke
collection PubMed
description Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by suppurative infection, sinus tract, and abscess formation. International management guidelines are largely consensus-based. Botulinum toxin (BTX) has been widely used in the treatment of apocrine and eccrine gland disorders, such as hyperhidrosis, although the effectiveness of BTX in the treatment of HS remains unknown. The aim of this systematic review was to understand the published evidence of BTX safety and effectiveness in the management of HS. METHODS: We conducted a PRISMA-compliant, prospectively registered (PROSPERO, CRD42021228732), systematic review. We devised bespoke search strategy and applied it to the Cochrane Central Register of Controlled Trials, Medline, Embase, and OpenGrey up until March 2022. We included all clinical studies that reported outcomes following BTX treatment in patients diagnosed with HS (both adult and pediatric). RESULTS: A total of 4658 studies were identified, of which six met full inclusion criteria reporting data on 26 patients. The six identified studies included one randomized control trial, one case series, and four case studies. The one included randomized control trial demonstrated a significant reduction in the Dermatology Life Quality Index score at 3 months following treatment with BTX. CONCLUSIONS: The effectiveness and safety of BTX in the treatment of HS remain unknown. This systematic review identified a paucity of high-quality clinical data. Evidence of treatment effectiveness is likely to come from registry-based cohort studies using established core outcome sets in the first instance.
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spelling pubmed-96744802022-11-21 The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review Geoghegan, Luke Rodrigues, Raina Harrison, Conrad J. Rodrigues, Jeremy N. Plast Reconstr Surg Glob Open Reconstructive Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by suppurative infection, sinus tract, and abscess formation. International management guidelines are largely consensus-based. Botulinum toxin (BTX) has been widely used in the treatment of apocrine and eccrine gland disorders, such as hyperhidrosis, although the effectiveness of BTX in the treatment of HS remains unknown. The aim of this systematic review was to understand the published evidence of BTX safety and effectiveness in the management of HS. METHODS: We conducted a PRISMA-compliant, prospectively registered (PROSPERO, CRD42021228732), systematic review. We devised bespoke search strategy and applied it to the Cochrane Central Register of Controlled Trials, Medline, Embase, and OpenGrey up until March 2022. We included all clinical studies that reported outcomes following BTX treatment in patients diagnosed with HS (both adult and pediatric). RESULTS: A total of 4658 studies were identified, of which six met full inclusion criteria reporting data on 26 patients. The six identified studies included one randomized control trial, one case series, and four case studies. The one included randomized control trial demonstrated a significant reduction in the Dermatology Life Quality Index score at 3 months following treatment with BTX. CONCLUSIONS: The effectiveness and safety of BTX in the treatment of HS remain unknown. This systematic review identified a paucity of high-quality clinical data. Evidence of treatment effectiveness is likely to come from registry-based cohort studies using established core outcome sets in the first instance. Lippincott Williams & Wilkins 2022-11-18 /pmc/articles/PMC9674480/ /pubmed/36415615 http://dx.doi.org/10.1097/GOX.0000000000004660 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Reconstructive
Geoghegan, Luke
Rodrigues, Raina
Harrison, Conrad J.
Rodrigues, Jeremy N.
The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review
title The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review
title_full The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review
title_fullStr The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review
title_full_unstemmed The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review
title_short The Use of Botulinum Toxin in the Management of Hidradenitis Suppurativa: A Systematic Review
title_sort use of botulinum toxin in the management of hidradenitis suppurativa: a systematic review
topic Reconstructive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674480/
https://www.ncbi.nlm.nih.gov/pubmed/36415615
http://dx.doi.org/10.1097/GOX.0000000000004660
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