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Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel

ELIC is a prokaryotic homopentameric ligand-gated ion channel that is homologous to vertebrate nicotinic acetylcholine receptors. Acetylcholine binds to ELIC but fails to activate it, despite bringing about conformational changes indicative of activation. Instead, acetylcholine competitively inhibit...

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Detalles Bibliográficos
Autores principales:	Slobodyanyuk, Mykhaylo, Banda-Vázquez, Jesús A., Thompson, Mackenzie J., Dean, Rebecca A., Baenziger, John E., Chica, Roberto A., daCosta, Corrie J. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674596/ https://www.ncbi.nlm.nih.gov/pubmed/36400839 http://dx.doi.org/10.1038/s42003-022-04227-6

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