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Impact of pulmonary African trypanosomes on the immunology and function of the lung
Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role of the parasite. Here we show that tsetse fly-transmitted Trypanosoma brucei parasites rapidly and permanently colonize the lungs and occupy the extravascular spaces surrounding th...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674601/ https://www.ncbi.nlm.nih.gov/pubmed/36400767 http://dx.doi.org/10.1038/s41467-022-34757-w |
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author | Mabille, Dorien Dirkx, Laura Thys, Sofie Vermeersch, Marjorie Montenye, Daniel Govaerts, Matthias Hendrickx, Sarah Takac, Peter Van Weyenbergh, Johan Pintelon, Isabel Delputte, Peter Maes, Louis Pérez-Morga, David Timmermans, Jean-Pierre Caljon, Guy |
author_facet | Mabille, Dorien Dirkx, Laura Thys, Sofie Vermeersch, Marjorie Montenye, Daniel Govaerts, Matthias Hendrickx, Sarah Takac, Peter Van Weyenbergh, Johan Pintelon, Isabel Delputte, Peter Maes, Louis Pérez-Morga, David Timmermans, Jean-Pierre Caljon, Guy |
author_sort | Mabille, Dorien |
collection | PubMed |
description | Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role of the parasite. Here we show that tsetse fly-transmitted Trypanosoma brucei parasites rapidly and permanently colonize the lungs and occupy the extravascular spaces surrounding the blood vessels of the alveoli and bronchi. They are present as nests of multiplying parasites exhibiting close interactions with collagen and active secretion of extracellular vesicles. The local immune response shows a substantial increase of monocytes, macrophages, dendritic cells and γδ and activated αβ T cells and a later influx of neutrophils. Interestingly, parasite presence results in a significant reduction of B cells, eosinophils and natural killer cells. T. brucei infected mice show no infection-associated pulmonary dysfunction, mirroring the limited pulmonary clinical complications during sleeping sickness. However, the substantial reduction of the various immune cells may render individuals more susceptible to opportunistic infections, as evident by a co-infection experiment with respiratory syncytial virus. Collectively, these observations provide insights into a largely overlooked target organ, and may trigger new diagnostic and supportive therapeutic approaches for sleeping sickness. |
format | Online Article Text |
id | pubmed-9674601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96746012022-11-20 Impact of pulmonary African trypanosomes on the immunology and function of the lung Mabille, Dorien Dirkx, Laura Thys, Sofie Vermeersch, Marjorie Montenye, Daniel Govaerts, Matthias Hendrickx, Sarah Takac, Peter Van Weyenbergh, Johan Pintelon, Isabel Delputte, Peter Maes, Louis Pérez-Morga, David Timmermans, Jean-Pierre Caljon, Guy Nat Commun Article Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role of the parasite. Here we show that tsetse fly-transmitted Trypanosoma brucei parasites rapidly and permanently colonize the lungs and occupy the extravascular spaces surrounding the blood vessels of the alveoli and bronchi. They are present as nests of multiplying parasites exhibiting close interactions with collagen and active secretion of extracellular vesicles. The local immune response shows a substantial increase of monocytes, macrophages, dendritic cells and γδ and activated αβ T cells and a later influx of neutrophils. Interestingly, parasite presence results in a significant reduction of B cells, eosinophils and natural killer cells. T. brucei infected mice show no infection-associated pulmonary dysfunction, mirroring the limited pulmonary clinical complications during sleeping sickness. However, the substantial reduction of the various immune cells may render individuals more susceptible to opportunistic infections, as evident by a co-infection experiment with respiratory syncytial virus. Collectively, these observations provide insights into a largely overlooked target organ, and may trigger new diagnostic and supportive therapeutic approaches for sleeping sickness. Nature Publishing Group UK 2022-11-18 /pmc/articles/PMC9674601/ /pubmed/36400767 http://dx.doi.org/10.1038/s41467-022-34757-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mabille, Dorien Dirkx, Laura Thys, Sofie Vermeersch, Marjorie Montenye, Daniel Govaerts, Matthias Hendrickx, Sarah Takac, Peter Van Weyenbergh, Johan Pintelon, Isabel Delputte, Peter Maes, Louis Pérez-Morga, David Timmermans, Jean-Pierre Caljon, Guy Impact of pulmonary African trypanosomes on the immunology and function of the lung |
title | Impact of pulmonary African trypanosomes on the immunology and function of the lung |
title_full | Impact of pulmonary African trypanosomes on the immunology and function of the lung |
title_fullStr | Impact of pulmonary African trypanosomes on the immunology and function of the lung |
title_full_unstemmed | Impact of pulmonary African trypanosomes on the immunology and function of the lung |
title_short | Impact of pulmonary African trypanosomes on the immunology and function of the lung |
title_sort | impact of pulmonary african trypanosomes on the immunology and function of the lung |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674601/ https://www.ncbi.nlm.nih.gov/pubmed/36400767 http://dx.doi.org/10.1038/s41467-022-34757-w |
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