Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification

Pseudoxanthoma elasticum (PXE) is a multisystem, genetic, ectopic mineralization disorder with no effective treatment. Inhibition of tissue-nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous pyrophosphate (PPi). This study evaluated the ant...

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Detalles Bibliográficos
Autores principales: Soma, Kaori, Watanabe, Kengo, Izumi, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674622/
https://www.ncbi.nlm.nih.gov/pubmed/36400944
http://dx.doi.org/10.1038/s41598-022-23892-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674622/
https://www.ncbi.nlm.nih.gov/pubmed/36400944
http://dx.doi.org/10.1038/s41598-022-23892-5

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