HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy

Cutaneous melanoma is one of the most aggressive and lethal forms of skin cancer. Some specific driver mutations have been described in multiple oncogenes including BRAF and NRAS that are mutated in 60–70% and 15–20% of melanoma, respectively. The aim of this study was to evaluate the role of Small...

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Detalles Bibliográficos
Autores principales: Cristofani, Riccardo, Piccolella, Margherita, Montagnani Marelli, Marina, Tedesco, Barbara, Poletti, Angelo, Moretti, Roberta Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674643/
https://www.ncbi.nlm.nih.gov/pubmed/36400750
http://dx.doi.org/10.1038/s41419-022-05365-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674643/
https://www.ncbi.nlm.nih.gov/pubmed/36400750
http://dx.doi.org/10.1038/s41419-022-05365-9

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