The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis

Defects in RNA splicing have been linked to human disorders, but remain poorly explored in inflammatory bowel disease (IBD). Here, we report that expression of the chromatin and alternative splicing regulator HP1γ is reduced in ulcerative colitis (UC). Accordingly, HP1γ gene inactivation in the mous...

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Detalles Bibliográficos
Autores principales: Mata-Garrido, Jorge, Xiang, Yao, Chang-Marchand, Yunhua, Reisacher, Caroline, Ageron, Elisabeth, Guerrera, Ida Chiara, Casafont, Iñigo, Bruneau, Aurelia, Cherbuy, Claire, Treton, Xavier, Dumay, Anne, Ogier-Denis, Eric, Batsché, Eric, Costallat, Mickael, Revêchon, Gwladys, Eriksson, Maria, Muchardt, Christian, Arbibe, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674647/
https://www.ncbi.nlm.nih.gov/pubmed/36400769
http://dx.doi.org/10.1038/s41467-022-34556-3

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