Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

Centromere defects in Systemic Sclerosis (SSc) have remained unexplored despite the fact that many centromere proteins were discovered in patients with SSc. Here we report that lesion skin fibroblasts from SSc patients show marked alterations in centromeric DNA. SSc fibroblasts also show DNA damage,...

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Detalles Bibliográficos
Autores principales: Paul, Souren, Kaplan, Mark H., Khanna, Dinesh, McCourt, Preston M., Saha, Anjan K., Tsou, Pei-Suen, Anand, Mahek, Radecki, Alexander, Mourad, Mohamad, Sawalha, Amr H., Markovitz, David M., Contreras-Galindo, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674829/
https://www.ncbi.nlm.nih.gov/pubmed/36400785
http://dx.doi.org/10.1038/s41467-022-34775-8

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