A glutamine-based single α-helix scaffold to target globular proteins

The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer opportunities for therapeutic intervention but their modulation with small molecules is challenging because they bury large surfaces. Linear peptides that disp...

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Detalles Bibliográficos
Autores principales: Escobedo, Albert, Piccirillo, Jonathan, Aranda, Juan, Diercks, Tammo, Mateos, Borja, Garcia-Cabau, Carla, Sánchez-Navarro, Macarena, Topal, Busra, Biesaga, Mateusz, Staby, Lasse, Kragelund, Birthe B., García, Jesús, Millet, Oscar, Orozco, Modesto, Coles, Murray, Crehuet, Ramon, Salvatella, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674830/
https://www.ncbi.nlm.nih.gov/pubmed/36400768
http://dx.doi.org/10.1038/s41467-022-34793-6

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