Cargando…

Plasma exosomal miR-122 regulates the efficacy of metformin via AMPK in type 2 diabetes and hepatocellular carcinoma

Metformin is a drug that has been applied in clinical use for many years for the treatment of type 2 diabetes mellitus (T2DM). It achieves its function through multiple targets and modulation of multiple signaling pathways. To date, the mechanism of the action of metformin is still not fully underst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Hui, Hou, Mei, Wu, Zixin, Wang, Jing, Zhou, Man, Zhuang, Xiangjin, Xing, Jiayu, Tao, Qianqian, Huang, Long, Zhou, Fuhai, Zhang, Shengming, Feng, Qiyu, Hou, Yilin, Yu, Qinsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674877/ https://www.ncbi.nlm.nih.gov/pubmed/36411886 http://dx.doi.org/10.1016/j.heliyon.2022.e11503

Ejemplares similares

Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway
por: Sun, Yunpeng, et al.
Publicado: (2016)

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma
por: Lou, Guohua, et al.
Publicado: (2015)

Improving the Detection of Hepatocellular Carcinoma Using Serum AFP Expression in Combination with GPC3 and Micro-RNA MiR-122 Expression
por: Li, Jian, et al.
Publicado: (2019)

Metformin decreases miR-122, miR-223 and miR-29a in women with polycystic ovary syndrome
por: Udesen, Pernille Bækgaard, et al.
Publicado: (2020)

Association of circulating exosomal miR-122 levels with BAT activity in healthy humans
por: Okamatsu-Ogura, Yuko, et al.
Publicado: (2019)

miR-122 and hepatocellular carcinoma: from molecular biology to therapeutics
por: Fu, Xiao, et al.
Publicado: (2018)

Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals
por: Dai, Wenjuan, et al.
Publicado: (2019)

Early diagnostic evaluation of miR-122 and miR-224 as biomarkers for hepatocellular carcinoma
por: Amr, Khalda S., et al.
Publicado: (2017)

miR-122 Regulates Tumorigenesis in Hepatocellular Carcinoma by Targeting AKT3
por: Nassirpour, Rounak, et al.
Publicado: (2013)

Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine
por: Kishikawa, Takahiro, et al.
Publicado: (2015)

Serum exosomal miR-122-5p, GAS, and PGR in the non-invasive diagnosis of CAG
por: Liu, Naihua, et al.
Publicado: (2021)

Down‐regulated lncRNA SBF2‐AS1 in M2 macrophage‐derived exosomes elevates miR‐122‐5p to restrict XIAP, thereby limiting pancreatic cancer development
por: Yin, Zi, et al.
Publicado: (2020)

Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levels
por: Li, Changfei, et al.
Publicado: (2016)

Retraction: miR-122 Regulates Tumorigenesis in Hepatocellular Carcinoma by Targeting AKT3
Publicado: (2017)

Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors
por: Israelow, Benjamin, et al.
Publicado: (2014)

LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation
por: Cheng, Di, et al.
Publicado: (2018)

Serum exosomal miR-122 as a potential diagnostic and prognostic biomarker of colorectal cancer with liver metastasis
por: Sun, Li, et al.
Publicado: (2020)

Exosomal miR-122-5p is Related to the Degree of Myelosuppression Caused by Chemotherapy in Patients with Colorectal Cancer
por: Chen, Jinbao, et al.
Publicado: (2021)

Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122
por: Li, Lei, et al.
Publicado: (2018)

miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma
por: Liu, Angela M., et al.
Publicado: (2014)

Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
por: Song, Kyoungsub, et al.
Publicado: (2015)

MiR-122 Targets SerpinB3 and Is Involved in Sorafenib Resistance in Hepatocellular Carcinoma
por: Turato, Cristian, et al.
Publicado: (2019)

Prognostic significance of miR-122 expression after curative resection in patients with hepatocellular carcinoma
por: Ha, Sang Yun, et al.
Publicado: (2019)

Potential relative quantities of miR-122 and miR-150 to differentiate hepatocellular carcinoma from liver cirrhosis
por: Gumilas, Nur Signa Aini, et al.
Publicado: (2022)

Circulating microRNAs (miR‐16, miR‐22, miR‐122) expression and early diagnosis of hepatocellular carcinoma
por: Fang, Yujia, et al.
Publicado: (2022)

Plasma Exosomal miRNA-122-5p and miR-300-3p as Potential Markers for Transient Ischaemic Attack in Rats
por: Li, Dong-Bin, et al.
Publicado: (2018)

Protective effects of metformin against myocardial ischemia-reperfusion injury via AMPK-dependent suppression of NOX4
por: Shi, Yan, et al.
Publicado: (2021)

Metabolic regulation by the intestinal metformin-AMPK axis
por: Zhang, Song-Yang, et al.
Publicado: (2022)

miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
por: Qin, Haifeng, et al.
Publicado: (2015)

High glucose levels promote the proliferation of breast cancer cells through GTPases
por: Hou, Yilin, et al.
Publicado: (2017)

MiR-122 Reverses the Doxorubicin-Resistance in Hepatocellular Carcinoma Cells through Regulating the Tumor Metabolism
por: Pan, Chenwei, et al.
Publicado: (2016)

miR-122-mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma
por: Shyu, Yu-Chiau, et al.
Publicado: (2016)

The Predictive Efficacy of Serum Exosomal microRNA-122 and microRNA-148a for Hepatocellular Carcinoma Based on Smart Healthcare
por: Deng, Peng, et al.
Publicado: (2022)

Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway
por: Liu, Yuyang, et al.
Publicado: (2019)

Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells
por: Gao, Chun, et al.
Publicado: (2020)

Fusobacterium nucleatum promotes colorectal cancer metastasis by excretion of miR-122-5p from cells via exosomes
por: Zhang, Mengjiao, et al.
Publicado: (2023)

miR-122 promotes diabetic retinopathy through targeting TIMP3
por: Wang, Mingliang, et al.
Publicado: (2020)

Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
por: Cheng, Demin, et al.
Publicado: (2021)

Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway
por: Chen, Chunyang, et al.
Publicado: (2021)

Characterization of miR-122-independent propagation of HCV
por: Ono, Chikako, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t1ngqa60lndkvq5o30tvp19ucf