Cargando…
Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection
While waning immunity and SARS-CoV-2 variant immune escape continue to result in high infection rates worldwide, associations between longitudinal quantitative, qualitative, and functional humoral immune responses after SARS-CoV-2 infection remain unclear. In this study, we found significant waning...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675084/ https://www.ncbi.nlm.nih.gov/pubmed/36439767 http://dx.doi.org/10.1016/j.heliyon.2022.e11676 |
_version_ | 1784833285978849280 |
---|---|
author | Monroe, Jonathon M. Haralambieva, Iana H. Warner, Nathaniel D. Grill, Diane E. Quach, Huy Quang Kennedy, Richard B. |
author_facet | Monroe, Jonathon M. Haralambieva, Iana H. Warner, Nathaniel D. Grill, Diane E. Quach, Huy Quang Kennedy, Richard B. |
author_sort | Monroe, Jonathon M. |
collection | PubMed |
description | While waning immunity and SARS-CoV-2 variant immune escape continue to result in high infection rates worldwide, associations between longitudinal quantitative, qualitative, and functional humoral immune responses after SARS-CoV-2 infection remain unclear. In this study, we found significant waning of antibody against Spike S1 (R = −0.32, p = 0.035) and N protein (R = −0.39, p = 0.008), while RBD antibody moderately decreased (R = −0.19, p = 0.203). Likewise, neutralizing antibody titer (ND(50)) waned over time (R = −0.46, p = 0.001). In contrast, antibody avidity increased significantly over time for Spike S1 (R = 0.62, p = 6.0e−06), RBD (R = 0.54, p = 2.0e−04), and N (R = 0.33, p = 0.025) antibodies. Across all humoral responses, ND(50) strongly associated with Spike S1 (R = 0.85, p = 2.7e−13) and RBD (R = 0.78, p = 2.9e−10) antibodies. Our findings provide longitudinal insight into humoral immune responses after infection and imply the potential of Spike S1/RBD antibody titer as surrogate correlates of protection. |
format | Online Article Text |
id | pubmed-9675084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96750842022-11-21 Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection Monroe, Jonathon M. Haralambieva, Iana H. Warner, Nathaniel D. Grill, Diane E. Quach, Huy Quang Kennedy, Richard B. Heliyon Research Article While waning immunity and SARS-CoV-2 variant immune escape continue to result in high infection rates worldwide, associations between longitudinal quantitative, qualitative, and functional humoral immune responses after SARS-CoV-2 infection remain unclear. In this study, we found significant waning of antibody against Spike S1 (R = −0.32, p = 0.035) and N protein (R = −0.39, p = 0.008), while RBD antibody moderately decreased (R = −0.19, p = 0.203). Likewise, neutralizing antibody titer (ND(50)) waned over time (R = −0.46, p = 0.001). In contrast, antibody avidity increased significantly over time for Spike S1 (R = 0.62, p = 6.0e−06), RBD (R = 0.54, p = 2.0e−04), and N (R = 0.33, p = 0.025) antibodies. Across all humoral responses, ND(50) strongly associated with Spike S1 (R = 0.85, p = 2.7e−13) and RBD (R = 0.78, p = 2.9e−10) antibodies. Our findings provide longitudinal insight into humoral immune responses after infection and imply the potential of Spike S1/RBD antibody titer as surrogate correlates of protection. Elsevier 2022-11-19 /pmc/articles/PMC9675084/ /pubmed/36439767 http://dx.doi.org/10.1016/j.heliyon.2022.e11676 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Monroe, Jonathon M. Haralambieva, Iana H. Warner, Nathaniel D. Grill, Diane E. Quach, Huy Quang Kennedy, Richard B. Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection |
title | Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection |
title_full | Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection |
title_fullStr | Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection |
title_full_unstemmed | Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection |
title_short | Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection |
title_sort | longitudinal antibody titer, avidity, and neutralizing responses after sars-cov-2 infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675084/ https://www.ncbi.nlm.nih.gov/pubmed/36439767 http://dx.doi.org/10.1016/j.heliyon.2022.e11676 |
work_keys_str_mv | AT monroejonathonm longitudinalantibodytiteravidityandneutralizingresponsesaftersarscov2infection AT haralambievaianah longitudinalantibodytiteravidityandneutralizingresponsesaftersarscov2infection AT warnernathanield longitudinalantibodytiteravidityandneutralizingresponsesaftersarscov2infection AT grilldianee longitudinalantibodytiteravidityandneutralizingresponsesaftersarscov2infection AT quachhuyquang longitudinalantibodytiteravidityandneutralizingresponsesaftersarscov2infection AT kennedyrichardb longitudinalantibodytiteravidityandneutralizingresponsesaftersarscov2infection |