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Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis

INTRODUCTION: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a massive impact on the health sector, especially in patients with pre-existing comorbidities. This study aims to define the predictor factors for worse outcomes in kidney transplant patients infect...

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Autores principales: Duarsa, Gede Wirya Kusuma, Sugianto, Ronald, Yusari, I Gusti Agung Ayu Andra, Tirtayasa, Pande Made Wisnu, Situmorang, Gerhard Reinaldi, Rasyid, Nur, Rodjani, Arry, Daryanto, Besut, Seputra, Kurnia Penta, Satyagraha, Paksi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675086/
https://www.ncbi.nlm.nih.gov/pubmed/36414181
http://dx.doi.org/10.1016/j.trim.2022.101739
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author Duarsa, Gede Wirya Kusuma
Sugianto, Ronald
Yusari, I Gusti Agung Ayu Andra
Tirtayasa, Pande Made Wisnu
Situmorang, Gerhard Reinaldi
Rasyid, Nur
Rodjani, Arry
Daryanto, Besut
Seputra, Kurnia Penta
Satyagraha, Paksi
author_facet Duarsa, Gede Wirya Kusuma
Sugianto, Ronald
Yusari, I Gusti Agung Ayu Andra
Tirtayasa, Pande Made Wisnu
Situmorang, Gerhard Reinaldi
Rasyid, Nur
Rodjani, Arry
Daryanto, Besut
Seputra, Kurnia Penta
Satyagraha, Paksi
author_sort Duarsa, Gede Wirya Kusuma
collection PubMed
description INTRODUCTION: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a massive impact on the health sector, especially in patients with pre-existing comorbidities. This study aims to define the predictor factors for worse outcomes in kidney transplant patients infected with SARS-CoV-2 and affected by coronavirus disease 2019 (COVID-19). We have analyzed in these patients their prior medical history, their clinical symptoms, and their laboratory results. METHOD: We assessed outcomes of kidney transplant patients with confirmed COVID-19 until July 2021 from PubMed, Medline, Science Direct, Cochrane databases, EMBASE, Scopus, and EBSCO. We performed meta-analyses of nine published studies to estimate predictor factors. The analysis was analyzed by the Newcastle-Ottawa Scale (NOS) and then using the Review Manager 5.4 software. RESULT: Our analysis demonstrated that the most significant risk factors for the worse COVID-19 outcomes for kidney transplant patients included: age of 60 and older [MD 9.31(95% CI, 6.31–12.30), p < 0.0001, I2 = 76%], diabetic nephropathy [OR 2.13 (95% CI, 1.49–3.04), p < 0.0001, I2 = 76%], dyspnea [OR 4.53, (95% CI, 2.22–9.22), p < 0.0001, I2 = 76%], acute kidney injury (AKI) [OR 4.53 (95% CI, 1.10–5.21), p = 0.03, I2 = 58%], and some laboratory markers. Many patients had two or multiple risk factors in combination. CONCLUSION: Age and several comorbidities were the most significant factors for COVID-19 outcomes for kidney transplant recipients.
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spelling pubmed-96750862022-11-21 Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis Duarsa, Gede Wirya Kusuma Sugianto, Ronald Yusari, I Gusti Agung Ayu Andra Tirtayasa, Pande Made Wisnu Situmorang, Gerhard Reinaldi Rasyid, Nur Rodjani, Arry Daryanto, Besut Seputra, Kurnia Penta Satyagraha, Paksi Transpl Immunol Review INTRODUCTION: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a massive impact on the health sector, especially in patients with pre-existing comorbidities. This study aims to define the predictor factors for worse outcomes in kidney transplant patients infected with SARS-CoV-2 and affected by coronavirus disease 2019 (COVID-19). We have analyzed in these patients their prior medical history, their clinical symptoms, and their laboratory results. METHOD: We assessed outcomes of kidney transplant patients with confirmed COVID-19 until July 2021 from PubMed, Medline, Science Direct, Cochrane databases, EMBASE, Scopus, and EBSCO. We performed meta-analyses of nine published studies to estimate predictor factors. The analysis was analyzed by the Newcastle-Ottawa Scale (NOS) and then using the Review Manager 5.4 software. RESULT: Our analysis demonstrated that the most significant risk factors for the worse COVID-19 outcomes for kidney transplant patients included: age of 60 and older [MD 9.31(95% CI, 6.31–12.30), p < 0.0001, I2 = 76%], diabetic nephropathy [OR 2.13 (95% CI, 1.49–3.04), p < 0.0001, I2 = 76%], dyspnea [OR 4.53, (95% CI, 2.22–9.22), p < 0.0001, I2 = 76%], acute kidney injury (AKI) [OR 4.53 (95% CI, 1.10–5.21), p = 0.03, I2 = 58%], and some laboratory markers. Many patients had two or multiple risk factors in combination. CONCLUSION: Age and several comorbidities were the most significant factors for COVID-19 outcomes for kidney transplant recipients. Elsevier B.V. 2023-02 2022-11-19 /pmc/articles/PMC9675086/ /pubmed/36414181 http://dx.doi.org/10.1016/j.trim.2022.101739 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Duarsa, Gede Wirya Kusuma
Sugianto, Ronald
Yusari, I Gusti Agung Ayu Andra
Tirtayasa, Pande Made Wisnu
Situmorang, Gerhard Reinaldi
Rasyid, Nur
Rodjani, Arry
Daryanto, Besut
Seputra, Kurnia Penta
Satyagraha, Paksi
Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis
title Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis
title_full Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis
title_fullStr Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis
title_full_unstemmed Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis
title_short Predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: A systematic review and meta-analysis
title_sort predictor factor for worse outcomes in kidney transplant recipients infected with coronavirus disease 2019: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675086/
https://www.ncbi.nlm.nih.gov/pubmed/36414181
http://dx.doi.org/10.1016/j.trim.2022.101739
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