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Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot

Tetralogy of fallot (TOF) in the fetus is a typical congential heart disease that occurs during the early embryonic period, being characterized by the abnormal development of conus arteriosus. The early diagnosis and prevention of fetal TOF is very important and there is a great need for exploring t...

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Autores principales: Gou, Zhongshan, Zhou, Yan, Jia, Hongjing, Yang, Zhong, Zhang, Qian, Yan, Xinxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675103/
https://www.ncbi.nlm.nih.gov/pubmed/36402964
http://dx.doi.org/10.1186/s12884-022-05190-0
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author Gou, Zhongshan
Zhou, Yan
Jia, Hongjing
Yang, Zhong
Zhang, Qian
Yan, Xinxin
author_facet Gou, Zhongshan
Zhou, Yan
Jia, Hongjing
Yang, Zhong
Zhang, Qian
Yan, Xinxin
author_sort Gou, Zhongshan
collection PubMed
description Tetralogy of fallot (TOF) in the fetus is a typical congential heart disease that occurs during the early embryonic period, being characterized by the abnormal development of conus arteriosus. The early diagnosis and prevention of fetal TOF is very important and there is a great need for exploring the pathogenesis of it in clinic. In this study, there were three cases being detected with TOF by fetal echocardiogram and confirmed by autopsy. We characterize the difference of expression of lncRNAs and mRNAs through sequencing analysis of 3 pairs of myocardial tissues of fetal TOF and those of age-matched controls. Compared with normal group, there were 94 differentially expressed lncRNAs and 83 mRNA transcripts in TOF (P < 0.05). Correlation analysis between lncRNA and mRNA further showed that differentially expressed lncRNA can be linked to mRNAs, suggesting the potential regulator role of lncRNA in mRNA expression. Our data serve as a fundamental resource for understanding the disease etiology of TOF. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-022-05190-0.
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spelling pubmed-96751032022-11-20 Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot Gou, Zhongshan Zhou, Yan Jia, Hongjing Yang, Zhong Zhang, Qian Yan, Xinxin BMC Pregnancy Childbirth Research Tetralogy of fallot (TOF) in the fetus is a typical congential heart disease that occurs during the early embryonic period, being characterized by the abnormal development of conus arteriosus. The early diagnosis and prevention of fetal TOF is very important and there is a great need for exploring the pathogenesis of it in clinic. In this study, there were three cases being detected with TOF by fetal echocardiogram and confirmed by autopsy. We characterize the difference of expression of lncRNAs and mRNAs through sequencing analysis of 3 pairs of myocardial tissues of fetal TOF and those of age-matched controls. Compared with normal group, there were 94 differentially expressed lncRNAs and 83 mRNA transcripts in TOF (P < 0.05). Correlation analysis between lncRNA and mRNA further showed that differentially expressed lncRNA can be linked to mRNAs, suggesting the potential regulator role of lncRNA in mRNA expression. Our data serve as a fundamental resource for understanding the disease etiology of TOF. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-022-05190-0. BioMed Central 2022-11-19 /pmc/articles/PMC9675103/ /pubmed/36402964 http://dx.doi.org/10.1186/s12884-022-05190-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Gou, Zhongshan
Zhou, Yan
Jia, Hongjing
Yang, Zhong
Zhang, Qian
Yan, Xinxin
Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot
title Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot
title_full Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot
title_fullStr Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot
title_full_unstemmed Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot
title_short Prenatal diagnosis and mRNA profiles of fetal tetralogy of Fallot
title_sort prenatal diagnosis and mrna profiles of fetal tetralogy of fallot
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675103/
https://www.ncbi.nlm.nih.gov/pubmed/36402964
http://dx.doi.org/10.1186/s12884-022-05190-0
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