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Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review
BACKGROUND: Erosion is one of the most common and basic lesions of oral mucosal diseases. Long-term refractory oral erosions, induced by autoimmune blistering diseases, infectious diseases, malignant diseases, and some rare conditions, may substantially reduce the quality of life of patients or even...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675221/ https://www.ncbi.nlm.nih.gov/pubmed/36402984 http://dx.doi.org/10.1186/s12903-022-02567-7 |
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author | Wu, Yuqi Zhang, You Li, Chunyu Xie, Yulang Jiang, Sixin Jiang, Yuchen Qiu, Yan Luo, Xiaobo Chen, Qianming |
author_facet | Wu, Yuqi Zhang, You Li, Chunyu Xie, Yulang Jiang, Sixin Jiang, Yuchen Qiu, Yan Luo, Xiaobo Chen, Qianming |
author_sort | Wu, Yuqi |
collection | PubMed |
description | BACKGROUND: Erosion is one of the most common and basic lesions of oral mucosal diseases. Long-term refractory oral erosions, induced by autoimmune blistering diseases, infectious diseases, malignant diseases, and some rare conditions, may substantially reduce the quality of life of patients or even constitute a life-threatening condition, resulting in a clinical dilemma regarding the accurate diagnosis and precise management of these diseases. As a special type of malignant lymphoma, most lesions of follicular lymphoma (FL) in the oral mucosa present as masses or swelling of the oral mucosa, while emerging novel presentations lead to intractable diagnoses. Hence, diagnostic algorithms for such diseases are clinically required. CASE PRESENTATION: A 55-year-old female patient presented to the clinic with long-lasting oral mucosal erosions and proliferative lesions. Blood tests, pathological examinations of oral lesions including haematoxylin–eosin (HE) staining, and direct immunofluorescence precluded all of the potential diagnoses described previously. Unexpectedly, positron emission tomography/computed tomography (PET/CT) and abdominal CT of the patient revealed a dense mass in the retroperitoneal area, and the final diagnosis of the retroperitoneal mass was FL. After three courses of chemotherapy conducted by the haematologist, the erosion and proliferative lesions in the patient's oral mucosa had significantly improved. HE and immunohistochemical staining results of intraoral lesions also confirmed it as oral FL. The successful diagnosis of FL in this case is of great clinical significance, as the oral and abdominal FL were treated in a timely manner to avoid unfavourable outcomes. CONCLUSIONS: To the best of our knowledge, this is the first case of FL that exhibited widespread erosions interspersed with proliferative lesions. Clinicians should be aware of oral FL or seek systemic factors in the presence of similar refractory oral erosions when treatment is non-responsive and the diagnosis is intractable. |
format | Online Article Text |
id | pubmed-9675221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-96752212022-11-20 Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review Wu, Yuqi Zhang, You Li, Chunyu Xie, Yulang Jiang, Sixin Jiang, Yuchen Qiu, Yan Luo, Xiaobo Chen, Qianming BMC Oral Health Case Report BACKGROUND: Erosion is one of the most common and basic lesions of oral mucosal diseases. Long-term refractory oral erosions, induced by autoimmune blistering diseases, infectious diseases, malignant diseases, and some rare conditions, may substantially reduce the quality of life of patients or even constitute a life-threatening condition, resulting in a clinical dilemma regarding the accurate diagnosis and precise management of these diseases. As a special type of malignant lymphoma, most lesions of follicular lymphoma (FL) in the oral mucosa present as masses or swelling of the oral mucosa, while emerging novel presentations lead to intractable diagnoses. Hence, diagnostic algorithms for such diseases are clinically required. CASE PRESENTATION: A 55-year-old female patient presented to the clinic with long-lasting oral mucosal erosions and proliferative lesions. Blood tests, pathological examinations of oral lesions including haematoxylin–eosin (HE) staining, and direct immunofluorescence precluded all of the potential diagnoses described previously. Unexpectedly, positron emission tomography/computed tomography (PET/CT) and abdominal CT of the patient revealed a dense mass in the retroperitoneal area, and the final diagnosis of the retroperitoneal mass was FL. After three courses of chemotherapy conducted by the haematologist, the erosion and proliferative lesions in the patient's oral mucosa had significantly improved. HE and immunohistochemical staining results of intraoral lesions also confirmed it as oral FL. The successful diagnosis of FL in this case is of great clinical significance, as the oral and abdominal FL were treated in a timely manner to avoid unfavourable outcomes. CONCLUSIONS: To the best of our knowledge, this is the first case of FL that exhibited widespread erosions interspersed with proliferative lesions. Clinicians should be aware of oral FL or seek systemic factors in the presence of similar refractory oral erosions when treatment is non-responsive and the diagnosis is intractable. BioMed Central 2022-11-19 /pmc/articles/PMC9675221/ /pubmed/36402984 http://dx.doi.org/10.1186/s12903-022-02567-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Wu, Yuqi Zhang, You Li, Chunyu Xie, Yulang Jiang, Sixin Jiang, Yuchen Qiu, Yan Luo, Xiaobo Chen, Qianming Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review |
title | Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review |
title_full | Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review |
title_fullStr | Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review |
title_full_unstemmed | Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review |
title_short | Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review |
title_sort | follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675221/ https://www.ncbi.nlm.nih.gov/pubmed/36402984 http://dx.doi.org/10.1186/s12903-022-02567-7 |
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