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Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy

Currently, tumor treatments are characterized by intelligence, diversity and personalization, but the therapeutic reagents used are often limited in clinical efficacy due to problems with water solubility, targeting, stability and multidrug resistance. To remedy these shortcomings, the application o...

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Autores principales: Tian, Luyao, Li, Xia, Ji, Haixia, Yu, Qing, Yang, Mingjuan, Guo, Lanping, Huang, Luqi, Gao, Wenyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675272/
https://www.ncbi.nlm.nih.gov/pubmed/36402976
http://dx.doi.org/10.1186/s12951-022-01698-x
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author Tian, Luyao
Li, Xia
Ji, Haixia
Yu, Qing
Yang, Mingjuan
Guo, Lanping
Huang, Luqi
Gao, Wenyuan
author_facet Tian, Luyao
Li, Xia
Ji, Haixia
Yu, Qing
Yang, Mingjuan
Guo, Lanping
Huang, Luqi
Gao, Wenyuan
author_sort Tian, Luyao
collection PubMed
description Currently, tumor treatments are characterized by intelligence, diversity and personalization, but the therapeutic reagents used are often limited in clinical efficacy due to problems with water solubility, targeting, stability and multidrug resistance. To remedy these shortcomings, the application of multifunctional nanotechnology in the biomedical field has been widely studied. Synthetic melanin nanoparticles (MNPs) surfaces which contain highly reactive chemical groups such as carboxyl, hydroxyl and amine groups, can be used as a reaction platform on which to graft different functional components. In addition, MNPs easily adhere to substrate surface, and serve as a secondary reaction platform to modify it. The multifunctionality and intrinsic biocompatibility make melanin-like nanoparticles promising as a multifunctional and powerful nanoplatform for oncological applications. This paper first reviews the preparation methods, polymerization mechanisms and physicochemical properties of melanin including natural melanin and chemically synthesized melanin to guide scholars in MNP-based design. Then, recent advances in MNPs especially synthetic polydopamine (PDA) melanin for various medical oncological applications are systematically and thoroughly described, mainly focusing on bioimaging, photothermal therapy (PTT), and drug delivery for tumor therapy. Finally, based on the investigated literature, the current challenges and future directions for clinical translation are reasonably discussed, focusing on the innovative design of MNPs and further elucidation of pharmacokinetics. This paper is a timely and comprehensive and detailed study of the progress of MNPs in tumor therapy, especially PTT, and provides ideas for the design of personalized and customizable oncology nanomedicines to address the heterogeneity of the tumor microenvironment. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-96752722022-11-20 Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy Tian, Luyao Li, Xia Ji, Haixia Yu, Qing Yang, Mingjuan Guo, Lanping Huang, Luqi Gao, Wenyuan J Nanobiotechnology Review Currently, tumor treatments are characterized by intelligence, diversity and personalization, but the therapeutic reagents used are often limited in clinical efficacy due to problems with water solubility, targeting, stability and multidrug resistance. To remedy these shortcomings, the application of multifunctional nanotechnology in the biomedical field has been widely studied. Synthetic melanin nanoparticles (MNPs) surfaces which contain highly reactive chemical groups such as carboxyl, hydroxyl and amine groups, can be used as a reaction platform on which to graft different functional components. In addition, MNPs easily adhere to substrate surface, and serve as a secondary reaction platform to modify it. The multifunctionality and intrinsic biocompatibility make melanin-like nanoparticles promising as a multifunctional and powerful nanoplatform for oncological applications. This paper first reviews the preparation methods, polymerization mechanisms and physicochemical properties of melanin including natural melanin and chemically synthesized melanin to guide scholars in MNP-based design. Then, recent advances in MNPs especially synthetic polydopamine (PDA) melanin for various medical oncological applications are systematically and thoroughly described, mainly focusing on bioimaging, photothermal therapy (PTT), and drug delivery for tumor therapy. Finally, based on the investigated literature, the current challenges and future directions for clinical translation are reasonably discussed, focusing on the innovative design of MNPs and further elucidation of pharmacokinetics. This paper is a timely and comprehensive and detailed study of the progress of MNPs in tumor therapy, especially PTT, and provides ideas for the design of personalized and customizable oncology nanomedicines to address the heterogeneity of the tumor microenvironment. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-11-19 /pmc/articles/PMC9675272/ /pubmed/36402976 http://dx.doi.org/10.1186/s12951-022-01698-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Tian, Luyao
Li, Xia
Ji, Haixia
Yu, Qing
Yang, Mingjuan
Guo, Lanping
Huang, Luqi
Gao, Wenyuan
Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy
title Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy
title_full Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy
title_fullStr Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy
title_full_unstemmed Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy
title_short Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy
title_sort melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675272/
https://www.ncbi.nlm.nih.gov/pubmed/36402976
http://dx.doi.org/10.1186/s12951-022-01698-x
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