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Identification of vascular endothelial growth factor in preeclampsia in Iraqi women

Preeclampsia (PE) is a major obstetric syndrome and represents a pregnancy hypertensive disease affecting about 2–8% of pregnancies. Typically, it occurs after 20 weeks of pregnancy, being classified as early or late in accordance with the gestational age at diagnosis or delivery. An imbalance betwe...

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Autores principales: Al-Ghazali, Basima, Khadim, Muna, Hamza, Sara, Al-Haddad, Hawraa Sahib, Jumaah, Alaa Salah, Hadi, Najah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675300/
https://www.ncbi.nlm.nih.gov/pubmed/36420291
http://dx.doi.org/10.25122/jml-2021-0211
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author Al-Ghazali, Basima
Khadim, Muna
Hamza, Sara
Al-Haddad, Hawraa Sahib
Jumaah, Alaa Salah
Hadi, Najah
author_facet Al-Ghazali, Basima
Khadim, Muna
Hamza, Sara
Al-Haddad, Hawraa Sahib
Jumaah, Alaa Salah
Hadi, Najah
author_sort Al-Ghazali, Basima
collection PubMed
description Preeclampsia (PE) is a major obstetric syndrome and represents a pregnancy hypertensive disease affecting about 2–8% of pregnancies. Typically, it occurs after 20 weeks of pregnancy, being classified as early or late in accordance with the gestational age at diagnosis or delivery. An imbalance between angiogenic and antiangiogenic factors has an important role in the pathophysiology of PE. It was hypothesized that the dysfunctional endothelium contributes to the pathogenesis of PE. A change in the production of Vascular endothelial growth factor (VEGR), a biomarker of endothelial dysfunction, is associated with this disease, whether presenting an increase, decrease, or being at a normal level. This study examined the associations between VEGF and preeclampsia and the importance of this VEGF as a predictor of its severity. This case-control study included 50 patients with preeclampsia and 50 normotensive pregnant women in the control group. Venous blood was aspirated from each patient, and VEGF levels were measured from sera. The mean VEGF for patients with mild PE was 29.410±18.976 pg/ml, for those with severe PE it was 36.188±36.98 pg/ml, and for normotensive women it was 92.104±154.715 pg/ml. There were significant differences in VEGF levels between the studied groups (P=0.024). This study showed that serum VEGF levels were significantly reduced in patients with preeclampsia compared with normotensive pregnant women, suggesting marked endothelial dysfunction. This led to widespread vasoconstriction and, in turn, caused hypertension and proteinuria.
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spelling pubmed-96753002022-12-01 Identification of vascular endothelial growth factor in preeclampsia in Iraqi women Al-Ghazali, Basima Khadim, Muna Hamza, Sara Al-Haddad, Hawraa Sahib Jumaah, Alaa Salah Hadi, Najah J Med Life Original Article Preeclampsia (PE) is a major obstetric syndrome and represents a pregnancy hypertensive disease affecting about 2–8% of pregnancies. Typically, it occurs after 20 weeks of pregnancy, being classified as early or late in accordance with the gestational age at diagnosis or delivery. An imbalance between angiogenic and antiangiogenic factors has an important role in the pathophysiology of PE. It was hypothesized that the dysfunctional endothelium contributes to the pathogenesis of PE. A change in the production of Vascular endothelial growth factor (VEGR), a biomarker of endothelial dysfunction, is associated with this disease, whether presenting an increase, decrease, or being at a normal level. This study examined the associations between VEGF and preeclampsia and the importance of this VEGF as a predictor of its severity. This case-control study included 50 patients with preeclampsia and 50 normotensive pregnant women in the control group. Venous blood was aspirated from each patient, and VEGF levels were measured from sera. The mean VEGF for patients with mild PE was 29.410±18.976 pg/ml, for those with severe PE it was 36.188±36.98 pg/ml, and for normotensive women it was 92.104±154.715 pg/ml. There were significant differences in VEGF levels between the studied groups (P=0.024). This study showed that serum VEGF levels were significantly reduced in patients with preeclampsia compared with normotensive pregnant women, suggesting marked endothelial dysfunction. This led to widespread vasoconstriction and, in turn, caused hypertension and proteinuria. Carol Davila University Press 2022-10 /pmc/articles/PMC9675300/ /pubmed/36420291 http://dx.doi.org/10.25122/jml-2021-0211 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Al-Ghazali, Basima
Khadim, Muna
Hamza, Sara
Al-Haddad, Hawraa Sahib
Jumaah, Alaa Salah
Hadi, Najah
Identification of vascular endothelial growth factor in preeclampsia in Iraqi women
title Identification of vascular endothelial growth factor in preeclampsia in Iraqi women
title_full Identification of vascular endothelial growth factor in preeclampsia in Iraqi women
title_fullStr Identification of vascular endothelial growth factor in preeclampsia in Iraqi women
title_full_unstemmed Identification of vascular endothelial growth factor in preeclampsia in Iraqi women
title_short Identification of vascular endothelial growth factor in preeclampsia in Iraqi women
title_sort identification of vascular endothelial growth factor in preeclampsia in iraqi women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675300/
https://www.ncbi.nlm.nih.gov/pubmed/36420291
http://dx.doi.org/10.25122/jml-2021-0211
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