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The association of thrombophilia in women with severe obstetric complications
Thrombophilia, where multiple genetic and acquired risk factors interact synergistically, are associated with thrombosis and pregnancy-related complications. Despite being studied profusely, an inconsistent association exists between thrombophilia and pregnancy complications. Between 2018 and 2020,...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675312/ https://www.ncbi.nlm.nih.gov/pubmed/36420283 http://dx.doi.org/10.25122/jml-2022-0182 |
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author | Alzahrani, Faisal Mousa Al-Mulhim, Abdulaziz Shaikh, Saeed Sattar Aldossary, Maryam Ahmed Aldarmahi, Ahmed Alnaam, Yaser Al-Jamea, Lamiaa Hammad AL-Maqati, Thekra Elnagi, Elmoeiz Hassan, Fathelrahman Mahdi Muzaheed, |
author_facet | Alzahrani, Faisal Mousa Al-Mulhim, Abdulaziz Shaikh, Saeed Sattar Aldossary, Maryam Ahmed Aldarmahi, Ahmed Alnaam, Yaser Al-Jamea, Lamiaa Hammad AL-Maqati, Thekra Elnagi, Elmoeiz Hassan, Fathelrahman Mahdi Muzaheed, |
author_sort | Alzahrani, Faisal Mousa |
collection | PubMed |
description | Thrombophilia, where multiple genetic and acquired risk factors interact synergistically, are associated with thrombosis and pregnancy-related complications. Despite being studied profusely, an inconsistent association exists between thrombophilia and pregnancy complications. Between 2018 and 2020, ninety-three women with pregnancy complications were enrolled in the study. Twenty-five healthy pregnant women without pregnancy complications reported to the same hospital were also recruited as controls. Blood samples were tested for homocysteine, coagulation studies, and molecular diagnosis included FVL, PTH and MTHFR genes amplified using PCR strip assay (Vienna Lab Diagnostics, Austria). Other thrombophilia screening, including testing for AT, PC, and LA, were done by chromogenic assays (Dade Diagnostica, Munich, Germany). Homocysteine level was determined by fluorescence polarization immunoassay technology (Axsym, Abbot company, Germany). Overall, 29.03% of women with pregnancy complications had thrombophilia relative to 16% in the control group. However, the difference between the case and control groups did not reach a significant level (p=0.1175). Additionally, combined thrombophilia was more prevalent among cases (10.75%) than in the control group (4%). However, the difference did not reach statistical significance (p=0.1046). Our study demonstrated that the frequency of thrombophilia among healthy women was 16%, and among women with pregnancy-related complications, 29%. Relative to control, all measured thrombophilia markers were more frequent in women with pregnancy-related complications except for LA. Including all the studies on the Saudi population in a meta-analysis study could reveal more information about thrombophilia and pregnancy-related complications in our population. |
format | Online Article Text |
id | pubmed-9675312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96753122022-12-01 The association of thrombophilia in women with severe obstetric complications Alzahrani, Faisal Mousa Al-Mulhim, Abdulaziz Shaikh, Saeed Sattar Aldossary, Maryam Ahmed Aldarmahi, Ahmed Alnaam, Yaser Al-Jamea, Lamiaa Hammad AL-Maqati, Thekra Elnagi, Elmoeiz Hassan, Fathelrahman Mahdi Muzaheed, J Med Life Original Article Thrombophilia, where multiple genetic and acquired risk factors interact synergistically, are associated with thrombosis and pregnancy-related complications. Despite being studied profusely, an inconsistent association exists between thrombophilia and pregnancy complications. Between 2018 and 2020, ninety-three women with pregnancy complications were enrolled in the study. Twenty-five healthy pregnant women without pregnancy complications reported to the same hospital were also recruited as controls. Blood samples were tested for homocysteine, coagulation studies, and molecular diagnosis included FVL, PTH and MTHFR genes amplified using PCR strip assay (Vienna Lab Diagnostics, Austria). Other thrombophilia screening, including testing for AT, PC, and LA, were done by chromogenic assays (Dade Diagnostica, Munich, Germany). Homocysteine level was determined by fluorescence polarization immunoassay technology (Axsym, Abbot company, Germany). Overall, 29.03% of women with pregnancy complications had thrombophilia relative to 16% in the control group. However, the difference between the case and control groups did not reach a significant level (p=0.1175). Additionally, combined thrombophilia was more prevalent among cases (10.75%) than in the control group (4%). However, the difference did not reach statistical significance (p=0.1046). Our study demonstrated that the frequency of thrombophilia among healthy women was 16%, and among women with pregnancy-related complications, 29%. Relative to control, all measured thrombophilia markers were more frequent in women with pregnancy-related complications except for LA. Including all the studies on the Saudi population in a meta-analysis study could reveal more information about thrombophilia and pregnancy-related complications in our population. Carol Davila University Press 2022-10 /pmc/articles/PMC9675312/ /pubmed/36420283 http://dx.doi.org/10.25122/jml-2022-0182 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Alzahrani, Faisal Mousa Al-Mulhim, Abdulaziz Shaikh, Saeed Sattar Aldossary, Maryam Ahmed Aldarmahi, Ahmed Alnaam, Yaser Al-Jamea, Lamiaa Hammad AL-Maqati, Thekra Elnagi, Elmoeiz Hassan, Fathelrahman Mahdi Muzaheed, The association of thrombophilia in women with severe obstetric complications |
title | The association of thrombophilia in women with severe obstetric complications |
title_full | The association of thrombophilia in women with severe obstetric complications |
title_fullStr | The association of thrombophilia in women with severe obstetric complications |
title_full_unstemmed | The association of thrombophilia in women with severe obstetric complications |
title_short | The association of thrombophilia in women with severe obstetric complications |
title_sort | association of thrombophilia in women with severe obstetric complications |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675312/ https://www.ncbi.nlm.nih.gov/pubmed/36420283 http://dx.doi.org/10.25122/jml-2022-0182 |
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