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Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie
Excessive reactive oxygen species (ROS) may generate deleterious effects on biomolecules, such as DNA damage, protein oxidation and lipid peroxidation, causing cell and tissue damage and eventually leading to the pathogenesis of diseases, such as neurodegenerative diseases, ischemia/reperfusion ((I/...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675353/ https://www.ncbi.nlm.nih.gov/pubmed/36411826 http://dx.doi.org/10.2147/JIR.S383239 |
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author | Liang, Shufeng Tian, Xin Wang, Chunyan |
author_facet | Liang, Shufeng Tian, Xin Wang, Chunyan |
author_sort | Liang, Shufeng |
collection | PubMed |
description | Excessive reactive oxygen species (ROS) may generate deleterious effects on biomolecules, such as DNA damage, protein oxidation and lipid peroxidation, causing cell and tissue damage and eventually leading to the pathogenesis of diseases, such as neurodegenerative diseases, ischemia/reperfusion ((I/R)) injury, and inflammatory diseases. Therefore, the modulation of ROS can be an efficient means to relieve the aforementioned diseases. Several studies have verified that antioxidants such as Mitoquinone (a mitochondrial-targeted coenzyme Q10 derivative) can scavenge ROS and attenuate related diseases. Nanozymes, defined as nanomaterials with intrinsic enzyme-like properties that also possess antioxidant properties, are hence expected to be promising alternatives for the treatment of ROS-related diseases. This review introduces the types of nanozymes with inherent antioxidant activities, elaborates on various strategies (eg, controlling the size or shape of nanozymes, regulating the composition of nanozymes and environmental factors) for modulating their catalytic activities, and summarizes their performances in treating ROS-induced diseases. |
format | Online Article Text |
id | pubmed-9675353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-96753532022-11-20 Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie Liang, Shufeng Tian, Xin Wang, Chunyan J Inflamm Res Review Excessive reactive oxygen species (ROS) may generate deleterious effects on biomolecules, such as DNA damage, protein oxidation and lipid peroxidation, causing cell and tissue damage and eventually leading to the pathogenesis of diseases, such as neurodegenerative diseases, ischemia/reperfusion ((I/R)) injury, and inflammatory diseases. Therefore, the modulation of ROS can be an efficient means to relieve the aforementioned diseases. Several studies have verified that antioxidants such as Mitoquinone (a mitochondrial-targeted coenzyme Q10 derivative) can scavenge ROS and attenuate related diseases. Nanozymes, defined as nanomaterials with intrinsic enzyme-like properties that also possess antioxidant properties, are hence expected to be promising alternatives for the treatment of ROS-related diseases. This review introduces the types of nanozymes with inherent antioxidant activities, elaborates on various strategies (eg, controlling the size or shape of nanozymes, regulating the composition of nanozymes and environmental factors) for modulating their catalytic activities, and summarizes their performances in treating ROS-induced diseases. Dove 2022-11-15 /pmc/articles/PMC9675353/ /pubmed/36411826 http://dx.doi.org/10.2147/JIR.S383239 Text en © 2022 Liang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Liang, Shufeng Tian, Xin Wang, Chunyan Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie |
title | Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie |
title_full | Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie |
title_fullStr | Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie |
title_full_unstemmed | Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie |
title_short | Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie |
title_sort | nanozymes in the treatment of diseases caused by excessive reactive oxygen specie |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675353/ https://www.ncbi.nlm.nih.gov/pubmed/36411826 http://dx.doi.org/10.2147/JIR.S383239 |
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