Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report

BACKGROUND: Acute lymphoblastic leukemia (ALL) has the highest incidence among childhood hematologic cancers. Exposure to certain cytotoxic therapies for ALL is correlated with a higher risk of secondary malignancies. CASE: We report a rare case of a 6‐year‐old girl being diagnosed with secondary ac...

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Autores principales: Wang, Xiaoning, Ding, Ding, Liu, Yalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675377/
https://www.ncbi.nlm.nih.gov/pubmed/36164709
http://dx.doi.org/10.1002/cnr2.1717
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author Wang, Xiaoning
Ding, Ding
Liu, Yalin
author_facet Wang, Xiaoning
Ding, Ding
Liu, Yalin
author_sort Wang, Xiaoning
collection PubMed
description BACKGROUND: Acute lymphoblastic leukemia (ALL) has the highest incidence among childhood hematologic cancers. Exposure to certain cytotoxic therapies for ALL is correlated with a higher risk of secondary malignancies. CASE: We report a rare case of a 6‐year‐old girl being diagnosed with secondary acute myeloid leukemia (AML) during her maintenance phase of treatment for ALL with TEL‐AML1 fusion gene, approximately 17 months after the primary diagnosis. CONCLUSION: This case indicates that we should recognize the increased risk of secondary AML for pediatric ALL patients with TEL‐AML1 fusion gene if multiple alkylating drugs and inhibitors for topoisomerase II are included in induction chemotherapy.
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spelling pubmed-96753772022-11-21 Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report Wang, Xiaoning Ding, Ding Liu, Yalin Cancer Rep (Hoboken) Case Reports BACKGROUND: Acute lymphoblastic leukemia (ALL) has the highest incidence among childhood hematologic cancers. Exposure to certain cytotoxic therapies for ALL is correlated with a higher risk of secondary malignancies. CASE: We report a rare case of a 6‐year‐old girl being diagnosed with secondary acute myeloid leukemia (AML) during her maintenance phase of treatment for ALL with TEL‐AML1 fusion gene, approximately 17 months after the primary diagnosis. CONCLUSION: This case indicates that we should recognize the increased risk of secondary AML for pediatric ALL patients with TEL‐AML1 fusion gene if multiple alkylating drugs and inhibitors for topoisomerase II are included in induction chemotherapy. John Wiley and Sons Inc. 2022-09-26 /pmc/articles/PMC9675377/ /pubmed/36164709 http://dx.doi.org/10.1002/cnr2.1717 Text en © 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Wang, Xiaoning
Ding, Ding
Liu, Yalin
Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report
title Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report
title_full Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report
title_fullStr Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report
title_full_unstemmed Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report
title_short Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report
title_sort acute myeloid leukemia secondary to acute b lymphoblastic leukemia treated with maintenance therapy in a child: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675377/
https://www.ncbi.nlm.nih.gov/pubmed/36164709
http://dx.doi.org/10.1002/cnr2.1717
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AT liuyalin acutemyeloidleukemiasecondarytoacuteblymphoblasticleukemiatreatedwithmaintenancetherapyinachildacasereport

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