DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype

Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte-specific gene expression and increase of mesenchymal markers. Two...

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Detalles Bibliográficos
Autores principales: Sanna, Adriana, Phung, Bengt, Mitra, Shamik, Lauss, Martin, Choi, Jiyeon, Zhang, Tongwu, Njauw, Ching-Ni, Cordero, Eugenia, Harbst, Katja, Rosengren, Frida, Cabrita, Rita, Johansson, Iva, Isaksson, Karolin, Ingvar, Christian, Carneiro, Ana, Brown, Kevin, Tsao, Hensin, Andersson, My, Pietras, Kristian, Jönsson, Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675437/
https://www.ncbi.nlm.nih.gov/pubmed/36040798
http://dx.doi.org/10.1172/jci.insight.156577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675437/
https://www.ncbi.nlm.nih.gov/pubmed/36040798
http://dx.doi.org/10.1172/jci.insight.156577

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