Distinct pretreatment innate immune landscape and posttreatment T cell responses underlie immunotherapy-induced colitis

Immune-related adverse events represent a major hurdle to the success of immunotherapy. The immunological mechanisms underlying their development and relation to antitumor responses are poorly understood. By examining both systemic and tissue-specific immune changes induced by combination anti–CTLA-...

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Detalles Bibliográficos
Autores principales: Nahar, Kazi J., Marsh-Wakefield, Felix, Rawson, Robert V., Gide, Tuba N., Ferguson, Angela L., Allen, Ruth, Quek, Camelia, da Silva, Ines Pires, Tattersal, Stephen, Kiely, Christopher J., Sandanayake, Neomal, Carlino, Matteo S., McCaughan, Geoff, Wilmott, James S., Scolyer, Richard A., Long, Georgina V., Menzies, Alexander M., Palendira, Umaimainthan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675442/
https://www.ncbi.nlm.nih.gov/pubmed/36173679
http://dx.doi.org/10.1172/jci.insight.157839

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