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HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

Therapy with radiation plus cisplatin kills HPV(+) oropharyngeal squamous cell carcinomas (OPSCCs) by increasing reactive oxygen species beyond cellular antioxidant capacity. To explore why these standard treatments fail for some patients, we evaluated whether the variation in HPV oncoprotein levels...

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Detalles Bibliográficos
Autores principales:	Sannigrahi, Malay K., Rajagopalan, Pavithra, Lai, Ling, Liu, Xinyi, Sahu, Varun, Nakagawa, Hiroshi, Jalaly, Jalal B., Brody, Robert M., Morgan, Iain M., Windle, Bradford E., Wang, Xiaowei, Gimotty, Phyllis A., Kelly, Daniel P., White, Elizabeth A., Basu, Devraj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675449/ https://www.ncbi.nlm.nih.gov/pubmed/36134662 http://dx.doi.org/10.1172/jci.insight.159600

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