Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo

TGF-β plays a critical role in maintaining immune cells in a resting state by inhibiting cell activation and proliferation. Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART). We hypothesized that releasing cells from TGF-β–driven signaling...

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Detalles Bibliográficos
Autores principales: Samer, Sadia, Thomas, Yanique, Araínga, Mariluz, Carter, Crystal, Shirreff, Lisa M., Arif, Muhammad S., Avita, Juan M., Frank, Ines, McRaven, Michael D., Thuruthiyil, Christopher T., Heybeli, Veli B., Anderson, Meegan R., Owen, Benjamin, Gaisin, Arsen, Bose, Deepanwita, Simons, Lacy M., Hultquist, Judd F., Arthos, James, Cicala, Claudia, Sereti, Irini, Santangelo, Philip J., Lorenzo-Redondo, Ramon, Hope, Thomas J., Villinger, Francois J., Martinelli, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675457/
https://www.ncbi.nlm.nih.gov/pubmed/36125890
http://dx.doi.org/10.1172/jci.insight.162290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675457/
https://www.ncbi.nlm.nih.gov/pubmed/36125890
http://dx.doi.org/10.1172/jci.insight.162290

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