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IRF4 expression by lung dendritic cells drives acute but not Trm cell–dependent memory Th2 responses

Expression of the transcription factor interferon regulatory factor 4 (IRF4) is required for the development of lung conventional DCs type 2 (cDC2s) that elicit Th2 responses, yet how IRF4 functions in lung cDC2s throughout the acute and memory allergic response is not clear. Here, we used a mouse m...

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Detalles Bibliográficos
Autores principales: Camacho, Daniel F., Velez, Tania E., Hollinger, Maile K., Wang, Esther, Howard, Chanie L., Darnell, Eli P., Kennedy, Domenick E., Krishack, Paulette A., Hrusch, Cara L., Clark, Marcus R., Moon, James J., Sperling, Anne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675458/
https://www.ncbi.nlm.nih.gov/pubmed/36194494
http://dx.doi.org/10.1172/jci.insight.140384