VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system

Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with RNA sequencing in over 900 cancer cell lines, we found that cancers of nervous system lineage, including adult and pediatr...

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Detalles Bibliográficos
Autores principales: So, Jonathan, Mabe, Nathaniel W., Englinger, Bernhard, Chow, Kin-Hoe, Moyer, Sydney M., Yerrum, Smitha, Trissal, Maria C., Marques, Joana G., Kwon, Jason J., Shim, Brian, Pal, Sangita, Panditharatna, Eshini, Quinn, Thomas, Schaefer, Daniel A., Jeong, Daeun, Mayhew, David L., Hwang, Justin, Beroukhim, Rameen, Ligon, Keith L., Stegmaier, Kimberly, Filbin, Mariella G., Hahn, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675470/
https://www.ncbi.nlm.nih.gov/pubmed/36040810
http://dx.doi.org/10.1172/jci.insight.158755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675470/
https://www.ncbi.nlm.nih.gov/pubmed/36040810
http://dx.doi.org/10.1172/jci.insight.158755

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