Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus

The origin and mechanisms of autoantigen generation in systemic lupus erythematosus (SLE) are poorly understood. Here, we identified SLE neutrophils activated in vivo by IFN as a prominent source of Ro52, also known as tripartite motif–containing protein 21 (TRIM21), a critical autoantigen historica...

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Detalles Bibliográficos
Autores principales: Gomez-Bañuelos, Eduardo, Wahadat, M. Javad, Li, Jessica, Paz, Merlin, Antiochos, Brendan, Celia, Alessandra Ida, Andrade, Victoria, Ferris, Dylan P., Goldman, Daniel W., Darrah, Erika, Petri, Michelle, Andrade, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675474/
https://www.ncbi.nlm.nih.gov/pubmed/36040804
http://dx.doi.org/10.1172/jci.insight.163795

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