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Deficiency of inhibitory TLR4 homolog RP105 exacerbates fibrosis

Activation of TLR4 by its cognate damage-associated molecular patterns (DAMPs) elicits potent profibrotic effects and myofibroblast activation in systemic sclerosis (SSc), while genetic targeting of TLR4 or its DAMPs in mice accelerates fibrosis resolution. To prevent aberrant DAMP/TLR4 activity, a...

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Detalles Bibliográficos
Autores principales:	Wang, Wenxia, Bale, Swarna, Yalavarthi, Bharath, Verma, Priyanka, Tsou, Pei-Suen, Calderone, Ken M., Bhattacharyya, Dibyendu, Fisher, Gary J., Varga, John, Bhattacharyya, Swati
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675479/ https://www.ncbi.nlm.nih.gov/pubmed/36136452 http://dx.doi.org/10.1172/jci.insight.160684

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