Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy

Gene mutations causing loss of dystrophin result in the severe muscle disease known as Duchenne muscular dystrophy (DMD). Despite efforts at genetic repair, DMD therapy remains largely palliative. Loss of dystrophin destabilizes the sarcolemmal membrane, inducing mechanosensitive cation channels to...

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Detalles Bibliográficos
Autores principales: Lin, Brian L., Shin, Joseph Y., Jeffreys, William P.D., Wang, Nadan, Lukban, Clarisse A., Moorer, Megan C., Velarde, Esteban, Hanselman, Olivia A., Kwon, Seoyoung, Kannan, Suraj, Riddle, Ryan C., Ward, Christopher W., Pullen, Steven S., Filareto, Antonio, Kass, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675567/
https://www.ncbi.nlm.nih.gov/pubmed/36099033
http://dx.doi.org/10.1172/jci.insight.158906

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