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Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation

TRIM5α is an E3 ubiquitin ligase of the TRIM family that binds to the capsids of primate immunodeficiency viruses and blocks viral replication after cell entry. Here we investigate how synthesis of K63-linked polyubiquitin is upregulated by transient proximity of three RING domains in honeycomb-like...

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Detalles Bibliográficos
Autores principales:	Herkules, Frank, Yu, Corey H., Taylor, Alexander B., Dougherty, Vi, Weintraub, Susan T., Ivanov, Dmitri N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675739/ https://www.ncbi.nlm.nih.gov/pubmed/36402777 http://dx.doi.org/10.1038/s41467-022-34920-3

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