Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers

Transcriptome-wide association studies (TWAS) have successfully discovered many putative disease susceptibility genes. However, TWAS may suffer from inaccuracy of gene expression predictions due to inclusion of non-regulatory variants. By integrating prior knowledge of susceptible transcription fact...

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Detalles Bibliográficos
Autores principales: He, Jingni, Wen, Wanqing, Beeghly, Alicia, Chen, Zhishan, Cao, Chen, Shu, Xiao-Ou, Zheng, Wei, Long, Quan, Guo, Xingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675749/
https://www.ncbi.nlm.nih.gov/pubmed/36402776
http://dx.doi.org/10.1038/s41467-022-34888-0

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