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Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling

RIG-I/DDX58 plays a key role in host innate immunity. However, its therapeutic potential for inflammation-related cancers remains to be explored. Here we identify frameshift germline mutations of RIG-I occurring in patients with colon cancer. Accordingly, Rig-i(fs/fs) mice bearing a frameshift mutan...

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Detalles Bibliográficos
Autores principales:	Song, Jia, Zhao, Wei, Zhang, Xin, Tian, Wenyu, Zhao, Xuyang, Ma, Liang, Cao, Yongtong, Yin, Yuxin, Zhang, Xuehui, Deng, Xuliang, Lu, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675819/ https://www.ncbi.nlm.nih.gov/pubmed/36402769 http://dx.doi.org/10.1038/s41467-022-34885-3

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