BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination

Embryonic stem cells (ESCs) have a significantly lower mutation load compared to somatic cells, but the mechanisms that guard genomic integrity in ESCs remain largely unknown. Here we show that BNIP3-dependent mitophagy protects genomic integrity in mouse ESCs. Deletion of Bnip3 increases cellular r...

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Detalles Bibliográficos
Autores principales: Zhao, Qian, Liu, Kun, Zhang, Lin, Li, Zheng, Wang, Liang, Cao, Jiani, Xu, Youqing, Zheng, Aihua, Chen, Quan, Zhao, Tongbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675825/
https://www.ncbi.nlm.nih.gov/pubmed/36402748
http://dx.doi.org/10.1038/s41419-022-05413-4

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