Cargando…
Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study
OBJECTIVE: To analyze the positivity and levels of SARS-CoV-2 antibodies in vaccinated children to evaluate the humoral immune response of vaccination on pediatric population. Analysis on the causes of antibody positivity in unvaccinated children. METHODS: A retrospective study was conducted on chil...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676227/ https://www.ncbi.nlm.nih.gov/pubmed/36420275 http://dx.doi.org/10.3389/fimmu.2022.1030238 |
_version_ | 1784833545314762752 |
---|---|
author | Li, Jing Ge, Menglei Dai, Shuzhi Song, Qinwei Liu, Weijie Wang, Ying Xu, Wenjian Ma, Lijuan |
author_facet | Li, Jing Ge, Menglei Dai, Shuzhi Song, Qinwei Liu, Weijie Wang, Ying Xu, Wenjian Ma, Lijuan |
author_sort | Li, Jing |
collection | PubMed |
description | OBJECTIVE: To analyze the positivity and levels of SARS-CoV-2 antibodies in vaccinated children to evaluate the humoral immune response of vaccination on pediatric population. Analysis on the causes of antibody positivity in unvaccinated children. METHODS: A retrospective study was conducted on children who were admitted to the Children’s Hospital Affiliated to Capital Institute of Pediatrics. The clinical data of serological testing of SARS-CoV-2 immunoglobulin M (IgM) and IgG antibodies were collected from SARS-CoV-2 vaccinated or unvaccinated children with no evidence of prior novel coronavirus infection. Chemiluminescence immunoassay was utilized for the in vitro determination of SARS-CoV-2 antibodies. RESULTS: A total of 3,321 healthy children aged 6-11 years received two doses of inactivated SARS-CoV-2 vaccine. At 1 month after the second dose, the positive rate (96.5%) and levels [8.039 (interquartile range (IQR), 6.067-9.098)] of SARS-CoV-2 IgG antibodies reached the peak and remained at a high level for 2-3 months, after which the positive rate and level of vaccine-induced IgG antibody gradually decreased. Compared with 1 month after the second dose of vaccine, the positive rate of IgG antibody decreased to 70.4% at 7 months, and the antibody level decreased by 69.0%. A total of 945 children aged 3-5 years received one or two doses of inactivated vaccine. The positive rate and levels of SARS-CoV-2 IgG antibody in participants remained high for 3 months after vaccination. There was no gender-based difference in positive rate of IgG antibody in children aged 3-11 years old (P>0.05). Among the 5,309 unvaccinated children aged 0 day to 11 years, 105 (2.0%) were positive for SARS-CoV-2 IgG antibody, which was associated with passive infusion. The maternal humoral response to COVID-19 vaccination in noninfected pregnant women was transferred through the placenta to the fetus, and some children obtained SARS-CoV-2-positive antibodies through blood transfusion. CONCLUSIONS: Inactivated SARS-CoV-2 vaccines could induce robust humoral immune response that gradually declined within several months after the second dose. Therefore, it helps to determine whether children receive a booster dose and elicit a long-term memory immune response. Positive SARS-CoV-2 antibodies in unvaccinated children were associated with passive IgG antibody infusion. |
format | Online Article Text |
id | pubmed-9676227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96762272022-11-22 Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study Li, Jing Ge, Menglei Dai, Shuzhi Song, Qinwei Liu, Weijie Wang, Ying Xu, Wenjian Ma, Lijuan Front Immunol Immunology OBJECTIVE: To analyze the positivity and levels of SARS-CoV-2 antibodies in vaccinated children to evaluate the humoral immune response of vaccination on pediatric population. Analysis on the causes of antibody positivity in unvaccinated children. METHODS: A retrospective study was conducted on children who were admitted to the Children’s Hospital Affiliated to Capital Institute of Pediatrics. The clinical data of serological testing of SARS-CoV-2 immunoglobulin M (IgM) and IgG antibodies were collected from SARS-CoV-2 vaccinated or unvaccinated children with no evidence of prior novel coronavirus infection. Chemiluminescence immunoassay was utilized for the in vitro determination of SARS-CoV-2 antibodies. RESULTS: A total of 3,321 healthy children aged 6-11 years received two doses of inactivated SARS-CoV-2 vaccine. At 1 month after the second dose, the positive rate (96.5%) and levels [8.039 (interquartile range (IQR), 6.067-9.098)] of SARS-CoV-2 IgG antibodies reached the peak and remained at a high level for 2-3 months, after which the positive rate and level of vaccine-induced IgG antibody gradually decreased. Compared with 1 month after the second dose of vaccine, the positive rate of IgG antibody decreased to 70.4% at 7 months, and the antibody level decreased by 69.0%. A total of 945 children aged 3-5 years received one or two doses of inactivated vaccine. The positive rate and levels of SARS-CoV-2 IgG antibody in participants remained high for 3 months after vaccination. There was no gender-based difference in positive rate of IgG antibody in children aged 3-11 years old (P>0.05). Among the 5,309 unvaccinated children aged 0 day to 11 years, 105 (2.0%) were positive for SARS-CoV-2 IgG antibody, which was associated with passive infusion. The maternal humoral response to COVID-19 vaccination in noninfected pregnant women was transferred through the placenta to the fetus, and some children obtained SARS-CoV-2-positive antibodies through blood transfusion. CONCLUSIONS: Inactivated SARS-CoV-2 vaccines could induce robust humoral immune response that gradually declined within several months after the second dose. Therefore, it helps to determine whether children receive a booster dose and elicit a long-term memory immune response. Positive SARS-CoV-2 antibodies in unvaccinated children were associated with passive IgG antibody infusion. Frontiers Media S.A. 2022-11-07 /pmc/articles/PMC9676227/ /pubmed/36420275 http://dx.doi.org/10.3389/fimmu.2022.1030238 Text en Copyright © 2022 Li, Ge, Dai, Song, Liu, Wang, Xu and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Jing Ge, Menglei Dai, Shuzhi Song, Qinwei Liu, Weijie Wang, Ying Xu, Wenjian Ma, Lijuan Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study |
title | Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study |
title_full | Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study |
title_fullStr | Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study |
title_full_unstemmed | Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study |
title_short | Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study |
title_sort | post-vaccination sars-cov-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: a retrospective, single-center study |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676227/ https://www.ncbi.nlm.nih.gov/pubmed/36420275 http://dx.doi.org/10.3389/fimmu.2022.1030238 |
work_keys_str_mv | AT lijing postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy AT gemenglei postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy AT daishuzhi postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy AT songqinwei postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy AT liuweijie postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy AT wangying postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy AT xuwenjian postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy AT malijuan postvaccinationsarscov2seroprevalenceinchildrenaged311yearsandthepositivityinunvaccinatedchildrenaretrospectivesinglecenterstudy |